The Third School of Clinical Medicine, Southern Medical University, Guangdong Province, Guangzhou, 510515, China; Department of General Surgery, Southern Medical University Affiliated Fengxian Hospital, Shanghai, 201499, China.
School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangdong Province, Guangzhou, 510515, China.
Biochem Biophys Res Commun. 2022 Nov 5;628:104-109. doi: 10.1016/j.bbrc.2022.08.057. Epub 2022 Aug 30.
Metastasis is a major cause of breast cancer mortality and the current study found histone demethylase, KDM2A, expression to be negatively correlated with breast cancer metastasis. KDM2A knockdown greatly promoted migration and invasion of breast cancer cells. The histone demethylase activity of KDM2A downregulated EGF transcription and suppressed the EGF-TSPAN8 pathway. Inhibition of breast cancer cell migration was also dependent on the histone demethylase activity of KDM2A. A novel mechanism of KDM2A-suppression of the EGF-TSPAN8 pathway which inhibited breast cancer cell migration and invasion is reported.
转移是导致乳腺癌死亡的主要原因，本研究发现组蛋白去甲基化酶 KDM2A 的表达与乳腺癌转移呈负相关。KDM2A 敲低显著促进乳腺癌细胞的迁移和侵袭。KDM2A 的组蛋白去甲基酶活性下调 EGF 转录并抑制 EGF-TSPAN8 通路。乳腺癌细胞迁移的抑制也依赖于 KDM2A 的组蛋白去甲基酶活性。本研究报道了 KDM2A 抑制 EGF-TSPAN8 通路从而抑制乳腺癌细胞迁移和侵袭的新机制。
