Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:4864-4867. doi: 10.1109/EMBC48229.2022.9871016.
A readout device for a dual-functional neural observation system is presented. The authors separately developed the reading operation of an implantable CMOS image sensor and a setup for fast-scan cyclic voltammetry and implemented them together in a microcontroller-based device. The developed imaging readout device with a size of [Formula: see text] can reach the highest reading rate of 160 fps with a 120×268 pixel image sensor. The voltammetry function was verified through an experiment using commercial carbon fiber electrodes in phosphate-buffered saline. When the imaging is sequentially operated with 400 V/s-scan rate voltammetry from -0.4 to 1.3 V, the system can operate at up to 60 fps. With this system, calcium imaging and dopamine recording in a freely behaving mouse can be achieved together in a simpler manner. This study aims to be the basis for the development of an implantable multi-functional sensor.
一种双功能神经观察系统的读出设备被提出。作者分别开发了植入式 CMOS 图像传感器的读取操作和用于快速扫描循环伏安法的设置，并将它们一起集成在基于微控制器的设备中。所开发的成像读出设备尺寸为[公式：见正文]，可在 120×268 像素图像传感器上达到最高 160 fps 的读取速率。通过在磷酸盐缓冲盐水中使用商业碳纤维电极的实验验证了伏安法功能。当以 400 V/s 的扫描速率从-0.4 到 1.3 V 进行顺序成像伏安法时，系统可以以高达 60 fps 的速度运行。通过该系统，可以更简单地在自由活动的小鼠中同时进行钙成像和多巴胺记录。本研究旨在为开发植入式多功能传感器奠定基础。
