Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022:3985-3988. doi: 10.1109/EMBC48229.2022.9871397.
Cardiovascular disease (CVD) and especially atherosclerosis are chronic inflammatory diseases which cause the atherosclerotic plaque growth in the arterial vessels and the blood flow reduction. Stents have revolutionized the treatment of this disease to a great extent by restoring the blood flow in the vessel. The present study investigates the performance of the blood flow after stent implantation in patient-specific coronary artery and demonstrates the effect of using Newtonian vs. non-Newtonian blood fluid models in the distribution of endothelial shear stress. In particular, the Navier-Stokes and continuity equations were employed, and three non-Newtonian fluid models were investigated (Carreau, Carreau-Yasuda and the Casson model). Computational finite elements models were used for the simulation of blood flow. The comparison of the results demonstrates that the Newtonian fluid model underestimates the calculation of Endothelial Shear Stress, while the three non-Newtonian fluids present similar distribution of shear stress. Keywords: Blood flow dynamics, stented artery, non-Newtonian fluid. Clinical Relevance- This work demonstrates that when blood flow modeling is performed at stented arteries and predictive models are developed, the non-Newtonian nature of blood must be considered.
心血管疾病（CVD）特别是动脉粥样硬化是慢性炎症性疾病，会导致动脉血管中动脉粥样硬化斑块的生长和血流减少。支架在很大程度上通过恢复血管中的血流，彻底改变了这种疾病的治疗方法。本研究调查了支架植入后患者特定冠状动脉中的血流性能，并展示了在内皮剪切应力分布中使用牛顿和非牛顿血液流体模型的效果。具体来说，使用了纳维-斯托克斯方程和连续性方程，并研究了三种非牛顿流体模型（Carreau、Carreau-Yasuda 和 Casson 模型）。计算有限元模型用于模拟血流。结果比较表明，牛顿流体模型低估了内皮剪切应力的计算，而三种非牛顿流体表现出相似的剪切应力分布。关键词：血流动力学，支架动脉，非牛顿流体。临床相关性- 这项工作表明，在对支架动脉进行血流建模并开发预测模型时，必须考虑血液的非牛顿性质。
