男性避孕药的研发：从药物化学角度的探讨。

Male contraceptive development: A medicinal chemistry perspective.

机构信息

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD19SY, UK.

出版信息

Eur J Med Chem. 2022 Dec 5;243:114709. doi: 10.1016/j.ejmech.2022.114709. Epub 2022 Aug 25.

DOI:10.1016/j.ejmech.2022.114709

PMID:36087385

Abstract

There is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.

摘要

需要非激素避孕药。进一步研究的一个领域是男性避孕药的开发。对于男性中潜在的药物靶点以实现可逆避孕效果，人们的了解相对较少。在本文中，我们回顾了男性避孕药的需求，以及围绕男性避孕药的一些特征和潜在的开发途径的一些想法。然后，我们讨论了发现男性避孕药的不同潜在方法，然后强调了文献中讨论过的一些潜在靶点。