Mensurado Sofia, Silva-Santos Bruno
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Trends Cancer. 2022 Nov;8(11):881-883. doi: 10.1016/j.trecan.2022.08.006. Epub 2022 Sep 8.
In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17 γδ T cell subsets that promote its growth.
在《科学》杂志的一项研究中，赖斯等人描述了结直肠癌（CRC）中γδ T细胞活动的时间分离现象。最初，肿瘤监测由产生干扰素-γ（IFN-γ）的细胞毒性γδ T细胞亚群精心安排，但一旦肿瘤茁壮成长，它就会被促进其生长的白细胞介素（IL）-17 γδ T细胞亚群浸润。
