肠道中γδ T细胞亚群的较量

Battle of the γδ T cell subsets in the gut.

作者信息

Mensurado Sofia, Silva-Santos Bruno

机构信息

Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

出版信息

Trends Cancer. 2022 Nov;8(11):881-883. doi: 10.1016/j.trecan.2022.08.006. Epub 2022 Sep 8.

DOI:10.1016/j.trecan.2022.08.006

PMID:36088250

Abstract

In a study in Science, Reis et al. describe a temporal segregation of γδ T cell activities in colorectal cancer (CRC). Initially tumor surveillance is orchestrated by interferon-γ (IFN-γ)-producing and cytotoxic γδ T cell subsets, but once the tumor thrives, it becomes infiltrated by interleukin (IL)-17 γδ T cell subsets that promote its growth.

摘要

在《科学》杂志的一项研究中，赖斯等人描述了结直肠癌（CRC）中γδ T细胞活动的时间分离现象。最初，肿瘤监测由产生干扰素-γ（IFN-γ）的细胞毒性γδ T细胞亚群精心安排，但一旦肿瘤茁壮成长，它就会被促进其生长的白细胞介素（IL）-17 γδ T细胞亚群浸润。