Clermont Auvergne University, UPR 3533, Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), CRNH Auvergne, Clermont-Ferrand, France.
Biostatistics Unit, DRCI, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Obes Res Clin Pract. 2022 Sep-Oct;16(5):400-406. doi: 10.1016/j.orcp.2022.08.010. Epub 2022 Sep 7.
The current pediatric obesity health challenge necessitates a better understanding of the factors affecting weight loss success during interventions. The aim of this observational study was to test the impact of the rate of initial weight loss and body weight variability on weight loss during a 9-month residential, multidisciplinary weight loss program in adolescents with obesity.
This retrospective study considered a whole sample of 510 adolescents with obesity (12-16 years, 435 girls). Body weight assessment was performed before (T0) and each week during the 9 months of a multidisciplinary weight loss program. Initial weight change (week 4-W4) and overall weight change at week 12 (T1) and the end of the intervention (T2) were considered. Participants were divided into three groups (tertiles), based on their percentage of weight loss between T0 and W4; and weight variability was expressed by the root mean square error (RMSE) around each participant's regression line at each considered period (W4, T1, T2).
Adolescents with lower initial weight loss at W4 (tertile 3) displayed the lesser weight loss at T1 and T2 compared with adolescents in tertile 1 and 2. The RMSE was positively associated with the percentage of weight loss of the period considered, but when the analyses were adjusted for age and initial body weight, there was no more significant association.
The rate of weight loss during the first few weeks is crucial for weight loss success, and weight variability is positively associated with weight loss in adolescents with obesity. Overall, results show that initial body weight is a determinant characteristic to consider during a lifestyle intervention. Further studies are thus needed to better understand the relationship between body weight change patterns and weight loss during the dynamic state that is adolescence.
当前儿童肥胖的健康挑战需要更好地了解影响干预期间减肥成功的因素。本观察性研究旨在测试初始体重减轻率和体重变异性对肥胖青少年 9 个月住院多学科减肥计划期间减肥的影响。
本回顾性研究考虑了肥胖青少年（12-16 岁，435 名女孩）的全部样本。在多学科减肥计划的 9 个月期间，在每次就诊时评估体重。考虑了初始体重变化（第 4 周-W4）和第 12 周（T1）以及干预结束时（T2）的总体重变化。根据 T0 与 W4 之间体重减轻的百分比，将参与者分为三组（三分位数）；并通过每个参与者在每个考虑时期（W4、T1、T2）回归线上的均方根误差（RMSE）来表示体重变异性。
在 W4 时初始体重减轻较少的青少年（三分位数 3）在 T1 和 T2 时的体重减轻比三分位数 1 和 2 的青少年少。RMSE 与所考虑时期的体重减轻百分比呈正相关，但当分析调整为年龄和初始体重时，相关性不再显著。
前几周的体重减轻率对于减肥成功至关重要，体重变异性与肥胖青少年的体重减轻呈正相关。总体而言，结果表明初始体重是生活方式干预期间需要考虑的决定因素特征。因此，需要进一步研究以更好地了解青少年动态状态下体重变化模式与减肥之间的关系。
