三叉神经鞘瘤相关症状能否通过伽玛刀放射外科控制？

Can Trigeminal Schwannoma-Related Symptoms be Controlled With Gamma Knife Radiosurgery?

机构信息

Department of Neurosurgery, Kyung Hee University College of Medicine, Seoul, Republic of Korea.

出版信息

World Neurosurg. 2022 Nov;167:e1080-e1083. doi: 10.1016/j.wneu.2022.08.148. Epub 2022 Sep 8.

DOI:10.1016/j.wneu.2022.08.148

PMID:36089282

Abstract

OBJECTIVE

The effectiveness of gamma knife radiosurgery (GKRS) for the management of trigeminal schwannomas (TS) has been established. Although GKRS has been shown to inhibit tumor growth, the effect of GKRS on the symptoms caused by TS has not been sufficiently studied. In this study, symptomatic changes following GKRS for the management of symptomatic TS were investigated using long-term follow-up results.

METHODS

A retrospective analysis was performed on 32 patients with TS who underwent GKRS between May 1994 and December 2016. Clinical charts, radiographic results, and surgical records were reviewed. To evaluate whether symptoms improved after GKRS, patient demographics, GKRS profile, radiological tumor size change, and tumor location were analyzed.

RESULTS

Tumor control after GKRS for symptomatic TS was 87%. The improvement rates for facial pain at 6, 12, and 24 months after GKRS were 46%, 72%, and 86%, respectively. For the same time intervals, facial hypesthesia improved by 12%, 46%, and 52%, respectively. Of the patients with diplopia, 17% had improved symptoms 12 months after GKRS, and 50% of the patients improved after 24 months.

CONCLUSIONS

GKRS can be an effective treatment modality for TS tumor control and shows favorable results in improving TS-related symptom, especially facial pain.

摘要

目的

伽玛刀放射外科（GKRS）治疗三叉神经鞘瘤（TS）的有效性已得到证实。虽然 GKRS 已被证明能抑制肿瘤生长，但 GKRS 对 TS 引起的症状的影响尚未得到充分研究。本研究通过长期随访结果，探讨 GKRS 治疗症状性 TS 后症状的变化。

方法

回顾性分析了 1994 年 5 月至 2016 年 12 月间接受 GKRS 治疗的 32 例 TS 患者的临床资料、影像学结果和手术记录。为评估 GKRS 后症状是否改善，分析了患者的人口统计学特征、GKRS 特征、影像学肿瘤大小变化和肿瘤位置。

结果

GKRS 治疗症状性 TS 的肿瘤控制率为 87%。GKRS 后 6、12 和 24 个月时面部疼痛的改善率分别为 46%、72%和 86%。在相同的时间间隔内，面部感觉迟钝分别改善了 12%、46%和 52%。在出现复视的患者中，12 个月后有 17%的患者症状改善，24 个月后有 50%的患者症状改善。