比较前哨淋巴结活检术和选择性颈清扫术在临床颈部淋巴结阴性的早期口腔鳞状细胞癌患者中的应用：系统评价和荟萃分析。
Comparison of sentinel lymph node biopsy and elective neck dissection for early oral cavity squamous cell carcinoma patients with clinically node-negative necks: systematic review and meta-analysis.
机构信息
Department of Otorhinolaryngology - Head and Neck Surgery, Soonchunhyang University College of Medicine, Cheonan, Republic of Korea.
Department of Otolaryngology - Head and Neck Surgery, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
出版信息
J Laryngol Otol. 2023 Jun;137(6):599-607. doi: 10.1017/S0022215122002043. Epub 2022 Sep 12.
OBJECTIVE
This study aimed to compare the prognostic utility of sentinel node biopsy and elective neck dissection in early stage clinically node-negative oral cavity squamous cell carcinoma patients.
METHOD
PubMed, Scopus, Embase, Web of Science and Cochrane Library databases were searched up to March 2022. Hazard ratios, Kaplan-Meier curves, -values and survival outcomes were extracted.
RESULTS
Twelve studies involving 10 583 patients were included. No significant differences in overall survival between sentinel node biopsy and elective neck dissection groups were found. Heterogeneity was not detected in pooled overall survival, disease-free survival and disease-specific survival analyses (all I less than 50). In subgroup analyses by follow-up period, sentinel node biopsy and elective neck dissection had similar prognostic value.
CONCLUSION
Sentinel node biopsy might be a valuable alternative to elective neck dissection for the management of early stage clinically node-negative oral cavity squamous cell carcinoma.
目的
本研究旨在比较前哨淋巴结活检和选择性颈清扫术在临床淋巴结阴性口腔鳞状细胞癌患者中的预后作用。
方法
检索 PubMed、Scopus、Embase、Web of Science 和 Cochrane Library 数据库，检索截至 2022 年 3 月。提取风险比、Kaplan-Meier 曲线、P 值和生存结果。
结果
纳入 12 项涉及 10583 例患者的研究。前哨淋巴结活检组和选择性颈清扫组的总生存率无显著差异。汇总的总生存率、无病生存率和疾病特异性生存率分析中未检测到异质性（均 I 小于 50）。根据随访时间的亚组分析，前哨淋巴结活检和选择性颈清扫术具有相似的预后价值。
结论
对于临床淋巴结阴性口腔鳞状细胞癌的治疗，前哨淋巴结活检可能是选择性颈清扫术的一种有价值的替代方法。
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