Wei Yarui, Liang Xiuyuan, Guo Xiaotao, Wang Xiaoxiao, Qi Yunyi, Ali Rizwan, Wu Ming, Qian Ruobing, Wang Ming, Qiu Bensheng, Li Huawei, Fu Xianming, Chen Lin
Biomedical Engineering Center, School of Information Science and Technology, University of Science and Technology of China, Hefei, China.
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Neurosci. 2022 Aug 26;16:909796. doi: 10.3389/fnins.2022.909796. eCollection 2022.
Labor division of the two brain hemispheres refers to the dominant processing of input information on one side of the brain. At an early stage, or a preattentive stage, the right brain hemisphere is shown to dominate the auditory processing of tones, including lexical tones. However, little is known about the influence of brain damage on the labor division of the brain hemispheres for the auditory processing of linguistic tones. Here, we demonstrate swapped dominance of brain hemispheres at the preattentive stage of auditory processing of Chinese lexical tones after a stroke in the right temporal lobe (RTL). In this study, we frequently presented lexical tones to a group of patients with a stroke in the RTL and infrequently varied the tones to create an auditory contrast. The contrast evoked a mismatch negativity response, which indexes auditory processing at the preattentive stage. In the participants with a stroke in the RTL, the mismatch negativity response was lateralized to the left side, in contrast to the right lateralization pattern in the control participants. The swapped dominance of brain hemispheres indicates that the RTL is a core area for early-stage auditory tonal processing. Our study indicates the necessity of rehabilitating tonal processing functions for tonal language speakers who suffer an RTL injury.
大脑两半球的分工是指大脑一侧对输入信息进行主导处理。在早期阶段，即预注意阶段，右脑半球在包括声调在内的音调听觉处理中占主导地位。然而，关于脑损伤对大脑半球在声调语言听觉处理分工方面的影响，人们所知甚少。在此，我们证明了右颞叶（RTL）中风后，在汉语声调听觉处理的预注意阶段，大脑半球的主导地位发生了互换。在本研究中，我们频繁地向一组RTL中风患者呈现声调，并偶尔改变声调以制造听觉对比。这种对比引发了失配负波反应，该反应可作为预注意阶段听觉处理的指标。与对照组参与者的右侧化模式相反，RTL中风参与者的失配负波反应向左侧化。大脑半球主导地位的互换表明RTL是早期声调听觉处理的核心区域。我们的研究表明，对于遭受RTL损伤的声调语言使用者，恢复声调处理功能是必要的。
