Farias Clarisse de Azambuja, Cardoso Taiane de Azevedo, da Silva Marielle Moro, D'Angelo Francesca, Mondin Thaise Campos, Souza Luciano Dias de Mattos, da Silva Ricardo Azevedo, Kapczinski Flavio, Jansen Karen, Magalhães Pedro V S
Graduate Program in Psychiatry and Behavioral Sciences, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Graduate Program in Health and Behavior, Universidade Católica de Pelotas, Pelotas, Brazil.
Front Psychiatry. 2022 Aug 24;13:932484. doi: 10.3389/fpsyt.2022.932484. eCollection 2022.
In this report, we aim to assess the interaction of bipolar disorder and major depressive disorder with the evolution of social roles, economic classification, and substance misuse in emerging adults. This is a longitudinal population-based study ( = 231 at baseline), in which participants were reassessed at a mean of 5 years after baseline. A structured clinical interview was used to diagnose the participants with bipolar disorder and major depression; a control group without mood disorders was included. Men with mood disorders were less likely to be married in the beginning of the study and less likely to work in the follow-up. Women with major depression were less likely to study and more likely to be in a lower economic class at the beginning of the study. In comparison, women with bipolar disorder were less likely to live with their parents and more likely to live with their children in the first wave of the study. Substance misuse was more likely in people with mood disorders, especially in men, and women with bipolar disorder had the highest likelihood in the follow-up. Albeit longitudinal analyses were limited by a possibly insufficient sample size and mediating mechanisms for change, such as stigma, were not explored, the study suggests sex-related specificities regarding the change in social roles and substance use in people with mood disorders. Emerging adults, especially those with mood disorders, are in a period of change and instability and at a greater risk for substance use and abuse.
在本报告中，我们旨在评估双相情感障碍和重度抑郁症与新兴成年人社会角色演变、经济分类及物质滥用之间的相互作用。这是一项基于人群的纵向研究（基线时 = 231人），参与者在基线后平均5年接受重新评估。采用结构化临床访谈对参与者进行双相情感障碍和重度抑郁症的诊断；纳入了一个无心境障碍的对照组。患有心境障碍的男性在研究开始时结婚的可能性较小，在随访中工作的可能性较小。患有重度抑郁症的女性在研究开始时学习的可能性较小，处于较低经济阶层的可能性较大。相比之下，患有双相情感障碍的女性在研究的第一阶段与父母同住的可能性较小，与子女同住的可能性较大。物质滥用在患有心境障碍的人群中更常见，尤其是男性，而患有双相情感障碍的女性在随访中可能性最高。尽管纵向分析受到样本量可能不足的限制，且未探讨诸如耻辱感等变化的中介机制，但该研究表明了心境障碍患者在社会角色变化和物质使用方面存在性别相关的特异性。新兴成年人，尤其是那些患有心境障碍的人，正处于变化和不稳定时期，物质使用和滥用的风险更大。
