Jari Mohsen, Rastinmaram Zahra, Niazi Elahe, Mousavi Zahra
Department of Pediatric Rheumatology, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences, Isfahan, Iran.
SAGE Open Med Case Rep. 2022 Sep 6;10:2050313X221114727. doi: 10.1177/2050313X221114727. eCollection 2022.
Granulomatosis with polyangiitis disease is a rare vasculitis characterized by granulomatous inflammation of respiratory tracts and glomerulonephritis along with vasculitis of other organs. In this study, a 14- year-old boy was referred from ophthalmology clinic to the pediatric rheumatology ward due to drug-resistant conjunctivitis. He had a history of chronic rhinorrhea and nighttime coughing, and he was diagnosed with allergic rhinitis. Complete blood count showed leukocytosis and thrombocytosis, and the estimated sedimentation rate was elevated. Laboratory tests showed hematuria, proteinuria, and highly positive antineutrophil cytoplasmic antibody. Moreover, sinus computed tomography demonstrated pansinusitis, and spiral chest computed tomography showed multiple pulmonary nodules in both his lungs. Finally, based on renal biopsy, the patient was confirmed as a case of granulomatosis with polyangiitis. It is notable that acute or chronic conjunctivitis may be a manifestation of rheumatic diseases.
肉芽肿性多血管炎是一种罕见的血管炎，其特征为呼吸道的肉芽肿性炎症、肾小球肾炎以及其他器官的血管炎。在本研究中，一名14岁男孩因耐药性结膜炎从眼科诊所转诊至儿科风湿病病房。他有慢性鼻漏和夜间咳嗽病史，被诊断为过敏性鼻炎。全血细胞计数显示白细胞增多和血小板增多，估计血沉率升高。实验室检查显示血尿、蛋白尿以及抗中性粒细胞胞浆抗体高度阳性。此外，鼻窦计算机断层扫描显示全鼻窦炎，胸部螺旋计算机断层扫描显示双肺多发肺结节。最后，基于肾活检，该患者被确诊为肉芽肿性多血管炎病例。值得注意的是，急性或慢性结膜炎可能是风湿性疾病的一种表现。
