Kummer F
Eur J Nucl Med. 1987;13 Suppl:S2-5.
Clinical needs for noninvasive radionuclide methods have often been an important stimulus to further progress in techniques. In disorders such as pulmonary thromboembolism, however, the correct interpretation can only be made with the help of a broad synoptic basis, formed by the treating physician, the X-ray, and the nuclear medicine specialist. This trivial statement has been of topical interest over the past 20 years in the history of ventilation-perfusion (V-P) scanning. Considerable achievements and promising results have undoubtedly been obtained in the examination of aerosol clearance (alveolar permeability and mucociliary transport), regional ventilation, workup for malignancy, identification of inflammation of the parenchyma in the absence of radiological signs, and in noninvasive diagnosis of pulmonary blood flow and volume. Future developments may be very expensive and require highly specialized equipment (PET, cyclotron, etc.), with no assurance that routine clinical application will be available in the near future.
对无创性放射性核素方法的临床需求常常是推动技术进一步发展的重要动力。然而，在诸如肺血栓栓塞等疾病中，只有在治疗医师、X射线和核医学专家共同构建的广泛综合基础上，才能做出正确的解读。在过去20年通气-灌注（V-P）扫描的历史中，这句平凡的话一直备受关注。在气溶胶清除（肺泡通透性和黏液纤毛转运）检查、局部通气、恶性肿瘤诊断前的检查、无放射学征象时实质炎症的识别以及肺血流和容积的无创诊断方面，无疑已经取得了相当大的成就并获得了有前景的结果。未来的发展可能成本高昂，需要高度专业化的设备（正电子发射断层扫描、回旋加速器等），而且不能保证在不久的将来就能应用于常规临床。
