Cvelbar P, Culig J, Kopitar Z, Lenardic A, Smerkolj J U, Zorz M
Eur J Drug Metab Pharmacokinet. 1987 Jan-Mar;12(1):1-4. doi: 10.1007/BF03189854.
Eight healthy volunteers received an oral dose of 10 mg and an intravenous dose of 0.75 mg of dihydroergosine. Plasma concentrations were measured by HPLC method, and some pharmacokinetic parameters were calculated. The biologic half-life in the elimination phase was 8.35 +/- 1.87 h after oral administration and 8.84 +/- 3.64 h after intravenous administration. In both cases of administration a secondary rise in plasma concentration of dihydroergosine was observed, which can be attributed to hepatic recycling. The calculated bioavailability of the drug was 9.80 +/- 2.8%.
八名健康志愿者口服了10毫克双氢麦角碱，并静脉注射了0.75毫克双氢麦角碱。采用高效液相色谱法测定血浆浓度，并计算了一些药代动力学参数。口服给药后消除相的生物半衰期为8.35±1.87小时，静脉给药后为8.84±3.64小时。在两种给药情况下均观察到双氢麦角碱血浆浓度的二次升高，这可归因于肝肠循环。该药物计算得出的生物利用度为9.80±2.8%。
