天麻素治疗偏头痛的有效性：一项荟萃分析。
Effectiveness of gastrodin for migraine: A meta-analysis.
作者信息
Zhou Xiu, Shao Jingyi, Xie Xiuzhen, Xu Yingqi, Shao Tianyu, Jin Zhuqing
机构信息
The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Dongzhimen Hospital Beijing University of Chinese Medical, Beijing, China.
出版信息
Front Neurol. 2022 Aug 25;13:939401. doi: 10.3389/fneur.2022.939401. eCollection 2022.
BACKGROUND
Gastrodia elata Blume (GEB), a traditional Chinese medicine, has been widely used to treat dizziness, numbness of limbs, and infantile convulsion, among other issues. Gastrodin is the main component of GEB. This meta-analysis aimed to evaluate the efficacy and safety of gastrodin in the treatment of migraine.
METHODS
Ten electronic databases, namely the Cochrane Library, Embase, EBSCO, PubMed, Web of Science, CENTRAL, CNKI (China National Knowledge Infrastructure), CBM (Chinese Biomedicine Database), WanFang, and VIP (Chinese Scientific Journals Database), were searched for randomized controlled trials (RCTs) of gastrodin for migraine published before September 2021. The data were analyzed by RevMan 5.3 software and evaluated by GRADEpro.
RESULTS
A total of 1,332 subjects were included in 16 RCTs. The meta-analysis showed that gastrodin was significantly effective in treating migraine (RR = 1.21, 95%CI = [1.17, 1.27]), reducing the pain degree (MD = -1.65, 95% CI = [-2.28, -1.02]), reducing the frequency of migraine attack (SMD = -2.77, 95% CI = [-3.92, -1.62]), shortening the duration of migraine attack (SMD = -1.64, 95% CI = [-2.35, -0.93]), and slowing average arterial cerebral blood flow velocity (SMD = -3.19, 95% CI = [-5.21, -1.17]), as well as being safe.
CONCLUSIONS
This systematic review revealed gastrodin is effective and safe in the treatment of migraine.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197094, identifier: CRD42020197094.
背景
天麻是一种传统中药，已被广泛用于治疗头晕、肢体麻木和小儿惊厥等问题。天麻素是天麻的主要成分。本荟萃分析旨在评估天麻素治疗偏头痛的疗效和安全性。
方法
检索了10个电子数据库，即考克兰图书馆、Embase、EBSCO、PubMed、科学网、CENTRAL、中国知网、中国生物医学数据库、万方和维普，以查找2021年9月之前发表的关于天麻素治疗偏头痛的随机对照试验（RCT）。采用RevMan 5.3软件进行数据分析，并通过GRADEpro进行评估。
结果
16项RCT共纳入1332名受试者。荟萃分析表明，天麻素治疗偏头痛显著有效（RR = 1.21，95%CI = [1.17, 1.27]），可减轻疼痛程度（MD = -1.65，95%CI = [-2.28, -1.02]），降低偏头痛发作频率（SMD = -2.77，95%CI = [-3.92, -1.62]），缩短偏头痛发作持续时间（SMD = -1.64，95%CI = [-2.35, -0.93]），减慢平均动脉脑血流速度（SMD = -3.19，95%CI = [-5.21, -1.17]），且安全性良好。
结论
本系统评价显示天麻素治疗偏头痛有效且安全。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=197094，标识符：CRD42020197094。
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