Zhang Guangchong, Zhang Yiwen, Li Wenguan
School of Nursing, Henan Medical College, Zhengzhou 451191, Henan, China.
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
J Oncol. 2022 Aug 31;2022:5157398. doi: 10.1155/2022/5157398. eCollection 2022.
In cancer patients, a cardiovascular disease (CVD) is a prevalent occurrence. When a patient has both heart disease and cancer, the treatment can be complicated because treatment for one condition can have an adverse effect on the outcome of the other. A cardiovascular disease that involves heart failures, coronary artery disease (CAD), stroke, pericardial diseases, arrhythmias, and valve and vascular dysfunction is a serious worry for long-term cancer patients. Because preclinical research is limited, it is critical to comprehend the pathophysiology of CVD as a consequence of anticancerous therapies while taking into account the developing and expanding heart. As a result, in this research, we look at the epidemiological characteristics of cancer patients who also have cardiovascular illness. Low-dose chest computed tomography, cardiac CT, and cardiac magnetic resonance imaging (MRI) are used to acquire the data and perform the screening. Chemotherapeutic drugs such as anthracyclines and trastuzumab are used to treat the condition. Univariate analysis is used to examine risk factors and predict cardiovascular damage. Sensitivity, specificity, positive predictive value, negative predictive value, life expectancy, left ventricular ejection fraction (LVEF), and longitudinal strain are among the metrics examined.
在癌症患者中，心血管疾病（CVD）很常见。当患者同时患有心脏病和癌症时，治疗可能会很复杂，因为针对一种疾病的治疗可能会对另一种疾病的治疗结果产生不利影响。涉及心力衰竭、冠状动脉疾病（CAD）、中风、心包疾病、心律失常以及瓣膜和血管功能障碍的心血管疾病是长期癌症患者的一大严重担忧。由于临床前研究有限，在考虑发育中的和不断扩大的心脏的同时，了解抗癌治疗导致的心血管疾病的病理生理学至关重要。因此，在本研究中，我们观察了同时患有心血管疾病的癌症患者的流行病学特征。使用低剂量胸部计算机断层扫描、心脏CT和心脏磁共振成像（MRI）来获取数据并进行筛查。使用蒽环类药物和曲妥珠单抗等化疗药物来治疗该疾病。采用单因素分析来检查危险因素并预测心血管损伤。所检查的指标包括敏感性、特异性、阳性预测值、阴性预测值、预期寿命、左心室射血分数（LVEF）和纵向应变。
