O'Grady Ciara, O'Connor Cathal, Al Moosa Aysha, Murphy Michelle, Nic Dhonncha Eilis
Dermatology South Infirmary Victoria University Hospital Cork Ireland.
Medicine University College Cork College Road Cork Ireland.
Skin Health Dis. 2022 May 16;2(3):e125. doi: 10.1002/ski2.125. eCollection 2022 Sep.
Lichen sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the anogenital region, which can have significant impact on quality of life. Burden of treatment (BOT) is defined as the workload of healthcare experienced by patients and consequences on well-being. In this prospective study, 35 women with vulval LS completed a detailed Treatment Burden Questionnaire to assess their BOT. Nineteen (54.3%) achieved a score of 35 or less, signifying low BOT; ten (28.6%) between 36 and 65, signifying moderate BOT; and six (17.1%) above 65, signifying high BOT. Seven (20%) patients reported BOT scores of greater than 59, which has been designated as a cut-off for increased risk of treatment-related burnout. Higher BOT scores were moderately correlated with higher DLQI scores (r = 0.47, p < 0.01). BOT in LS is low for most patients, although a minority are at risk of treatment-related burnout. BOT should be considered when forming treatment guidelines for LS.
硬化性苔藓（LS）是一种主要累及肛门生殖器区域的慢性炎症性皮肤病，会对生活质量产生重大影响。治疗负担（BOT）被定义为患者所经历的医疗保健工作量及其对幸福感的影响。在这项前瞻性研究中，35名患有外阴LS的女性完成了一份详细的治疗负担问卷，以评估她们的BOT。19名（54.3%）患者的得分在35分及以下，表明治疗负担低；10名（28.6%）患者的得分在36至65分之间，表明治疗负担中等；6名（17.1%）患者的得分高于65分，表明治疗负担高。7名（20%）患者报告其BOT得分大于59分，该分数已被指定为治疗相关倦怠风险增加的临界值。较高的BOT得分与较高的皮肤病生活质量指数（DLQI）得分呈中度相关（r = 0.47，p < 0.01）。尽管少数患者有治疗相关倦怠的风险，但大多数LS患者的BOT较低。在制定LS的治疗指南时应考虑BOT。
