Ter Horst Rutger, Maal Thomas J J, de Koning Martien J J, Mertens Jorre S, Schatorjé Ellen J H, Hoppenreijs Esther P, Seyger Marieke M B
Department of Oral and Maxillofacial Surgery Radboud University Medical Center Nijmegen The Netherlands.
Department of Dermatology Radboud University Medical Center Nijmegen The Netherlands.
Skin Health Dis. 2022 Jul 5;2(3):e132. doi: 10.1002/ski2.132. eCollection 2022 Sep.
The diagnosis of Scleroderma En Coup de Sabre (ECDS)/Parry Romberg Syndrome (PRS) is mainly based on characteristic clinical findings. Methods to objectively monitor the course of the disease in a standardized way are lacking.
This descriptive, retrospective, single centre cohort study aims to describe the contribution of 3D photographs in the assessment of the degree of facial asymmetry changes over time in growing children and adolescents with ECDS and PRS.
Six patients diagnosed with ECDS/PRS, with a follow-up period of at least 24 months and at least three 3D photographs were included. Mirroring these 3D photographs was automatically performed using surface-based matching to generate a colour-coded distance map, illustrating the inter-surface distance and thereby asymmetry between the original and mirrored 3D photographs. The percentage of absolute distances between the original and mirrored 3D photograph were calculated.
In two patients, impressive decreases in the percentages of absolute distance levels over time were found, whereas the other patients did not show progression of asymmetry over time.
This study shows the potential of 3D stereophotogrammetry as an objective tool to measure disease activity over time in patients with ECDS/PRS.
剑伤性硬皮病（ECDS）/帕里-罗姆伯格综合征（PRS）的诊断主要基于特征性临床表现。目前缺乏以标准化方式客观监测疾病进程的方法。
这项描述性、回顾性、单中心队列研究旨在描述三维照片在评估患有ECDS和PRS的儿童及青少年面部不对称程度随时间变化中的作用。
纳入6例诊断为ECDS/PRS的患者，随访期至少24个月且至少有三张三维照片。使用基于表面的匹配自动对这些三维照片进行镜像处理，以生成彩色编码的距离图，显示表面间距离，从而说明原始三维照片与镜像三维照片之间的不对称性。计算原始三维照片与镜像三维照片之间绝对距离的百分比。
在两名患者中，发现绝对距离水平百分比随时间显著下降，而其他患者未显示不对称性随时间进展。
本研究表明三维立体摄影测量法作为一种客观工具，在测量ECDS/PRS患者疾病活动随时间变化方面具有潜力。
