Pham Michelle T, Pouratian Nader, Feinsinger Ashley
Center for Bioethics and Social Justice, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Neuroethics. 2022 Oct;15(3). doi: 10.1007/s12152-022-09502-1. Epub 2022 Aug 13.
Motivated by exploitation concerns, we argue for the importance of participant engagement in basic human intracranial electrophysiology research. This research takes advantage of unique neurosurgical opportunities to better understand complex systems of the human brain, but it also exposes participants to additional risks without immediate therapeutic intent. We argue that understanding participant values and incorporating their perspectives into the research process may (i) help determine whether and to what extent research practices and the resulting distributions of risks and benefits constitute exploitation and (ii) contribute to building a brain research paradigm that is genuinely responsive to participant values. More broadly, we highlight the importance of paying attention to participant interests in non-therapeutic brain research.
出于对剥削问题的关注，我们主张参与者参与人类颅内基础电生理研究的重要性。这项研究利用了独特的神经外科手术机会，以更好地理解人类大脑的复杂系统，但它也使参与者面临额外风险，且没有直接的治疗意图。我们认为，了解参与者的价值观并将他们的观点纳入研究过程可能（i）有助于确定研究实践以及由此产生的风险和利益分配是否构成剥削以及在何种程度上构成剥削，（ii）有助于建立一种真正响应参与者价值观的脑研究范式。更广泛地说，我们强调在非治疗性脑研究中关注参与者利益的重要性。
