Design, synthesis and biological evaluation of novel biphenylsulfonamide derivatives as selective AT receptor antagonists.

A novel series of benzenesulfonamide derivatives that selectively act on the AT receptor have been designed and synthesized. The binding affinity and functional activity were evaluated by radio-ligand binding analysis and cell neurite outgrowth assay, respectively. The compounds , , , , , and exhibited moderate selectivity and affinity for the AT receptor. Among them, exhibited agonist activity and displayed similar selectivity to the AT receptor with . Molecular docking was carried out to analyze the binding mode and binding site between the compound and the AT receptor to provide a reference for further development.