Kuzina N G
Farmakol Toksikol. 1987 May-Jun;50(3):46-9.
In cats with elevated systemic arterial blood pressure apilac (1 mg/kg, a single dose or course administration) significantly decreased the arterial vessel wall contents of ions of Na+, Ca2+ and catecholamines the levels of which exceeded control values. Apilac administration to animals with normal systemic arterial blood pressure resulted in a decrease of Ca2+ ion content, an increase of Na+, K+ and Mg2+ ion concentrations in the vessel wall. The content of catecholamines remained in the range of control values.
在全身动脉血压升高的猫中,阿皮拉克(1毫克/千克,单次剂量或疗程给药)显著降低了动脉血管壁中Na+、Ca2+离子和儿茶酚胺的含量,这些物质的水平超过了对照值。给全身动脉血压正常的动物施用阿皮拉克会导致血管壁中Ca2+离子含量降低,Na+、K+和Mg2+离子浓度升高。儿茶酚胺的含量保持在对照值范围内。