Katrukha S P, Kalenikov E I, Zagrebin S V, Kukes V G
Farmakol Toksikol. 1987 May-Jun;50(3):87-9.
Peculiarities of propranolol pharmacokinetics in patients with acute myocardial infarction were determined after oral administration of 80 mg of the drug and compared with control group of patients with stage II hypertensive disease: a significant increase of Cmax, Tmax and AUC without changes of kel and T1/2. A direct linear correlation (r = 0.86, p = 0.02) and inverse linear correlation (r = -0.54, p = 0.1) with the duration of the disease were revealed.
在口服80毫克普萘洛尔后，测定急性心肌梗死患者普萘洛尔的药代动力学特性，并与II期高血压病对照组患者进行比较：Cmax、Tmax和AUC显著增加，而kel和T1/2无变化。发现与疾病持续时间呈直接线性相关（r = 0.86，p = 0.02）和反向线性相关（r = -0.54，p = 0.1）。
