具有光滑内质网聚集的卵母细胞可能不会影响囊胚的整倍体率。
Oocytes With Smooth Endoplasmic Reticulum Aggregates May Not Impact Blastocyst Euploidy Rate.
机构信息
Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Aug 24;13:851370. doi: 10.3389/fendo.2022.851370. eCollection 2022.
OBJECTIVE
To investigate whether the euploidy rate of blastocysts derived from smooth endoplasmic reticulum aggregates (SERa) positive cycles and oocytes are impacted.
DESIGN
Retrospective cohort study.
METHODS
A total of 601 preimplantation genetic testing (PGT) cycles with at least one oocyte retrieved in our center between April 2017 and May 2021 were initially included in the study. Women>35 years and PGT cycles with chromosomal structural rearrangements (PGT-SR) were excluded. Embryological and blastocyst ploidy outcomes were compared among SERa+ oocyte, sibling SERa- oocytes and oocytes in SERa- cycles.
RESULTS
No significant difference was observed among the SERa+ oocyte group, sibling SERa- oocyte group, and SERa- cycle group in the normal fertilization rate (82.1% vs. 77.8% vs. 83.1%, respectively, =0.061), blastocyst formation rate (71.0% vs. 72.5% vs. 68.4%, respectively, =0.393), good quality blastocyst formation rate (46.4% vs. 48.3% vs. 42.6%, respectively, =0.198). No significant difference was observed in the euploidy rate (50.0% vs. 62.5% vs. 63.3%, respectively, =0.324), mosaic rate (12.5% vs. 9.7% vs. 13.4%, respectively, =0.506), and aneuploidy rate (37.5% vs. 27.8% vs. 23.2%, respectively, =0.137) among the three groups.
CONCLUSION
Our results suggest that the euploidy rate of blastocysts derived from SERa+ cycles and oocytes may not be impacted.
目的
探究卵母细胞中是否存在大量光滑内质网聚集（SERa）会影响囊胚的整倍体率。
设计
回顾性队列研究。
方法
本研究纳入了 2017 年 4 月至 2021 年 5 月期间在我院进行的至少有一枚卵母细胞被取出的 601 例胚胎植入前遗传学检测（PGT）周期。排除了>35 岁的女性和染色体结构重排（PGT-SR）的 PGT 周期。比较了 SERa+卵母细胞、SERA-卵母细胞和 SERa-周期中的卵母细胞的胚胎学和囊胚倍性结果。
结果
在正常受精率（分别为 82.1%、77.8%和 83.1%，=0.061）、囊胚形成率（分别为 71.0%、72.5%和 68.4%，=0.393）、优质囊胚形成率（分别为 46.4%、48.3%和 42.6%，=0.198）方面，SERa+卵母细胞组、SERA-卵母细胞组和 SERa-周期组之间无显著差异。三组之间的整倍体率（分别为 50.0%、62.5%和 63.3%，=0.324）、嵌合体率（分别为 12.5%、9.7%和 13.4%，=0.506）和非整倍体率（分别为 37.5%、27.8%和 23.2%，=0.137）也无显著差异。
结论
我们的研究结果表明，来自 SERa+周期和卵母细胞的囊胚的整倍体率可能不受影响。
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