接受抗CD20治疗的患者的双相性COVID-19临床病程：病例系列及文献综述
A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature.
作者信息
Bigman-Peer Noa, Peer Eyal, Pertzov Barak, Kramer Mordechai, Segal Gad, Eliakim-Raz Noa
机构信息
Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
Oncology Institute, Sheba Medical Center, Ramat Gan, Israel.
出版信息
Eur J Case Rep Intern Med. 2022 Aug 31;9(8):003502. doi: 10.12890/2022_003502. eCollection 2022.
UNLABELLED
We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after convalescence from initial mild to asymptomatic infection. Possible explanations are discussed.
LEARNING POINTS
Four cases of COVID-19 infection in anti-CD20 treated patients are described.These cases display a unique biphasic course that was previously undescribed: respiratory deterioration weeks after convalescence.Awareness of such a course and rapid utilisation of bronchoalveolar lavage will lead to quicker diagnosis and more timely, appropriate treatment.
未标注
我们描述了在奥密克戎毒株流行期间，接受抗CD20单克隆抗体治疗的患者中4例新冠病毒感染病例。所有病例均呈现相似的双相临床病程，包括呼吸功能恶化，这发生在从最初的轻度至无症状感染康复数周后。文中讨论了可能的原因。
学习要点
描述了4例接受抗CD20治疗的患者感染新冠病毒的病例。这些病例呈现出一种此前未被描述过的独特双相病程：康复数周后出现呼吸功能恶化。认识到这种病程并迅速进行支气管肺泡灌洗将有助于更快诊断并更及时、恰当地进行治疗。
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