Department of Otolaryngology-Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai, China.
Department of Respiratory, Children's Hospital of Fudan University, Shanghai, China.
Acta Otolaryngol. 2022 Sep-Dec;142(9-12):691-695. doi: 10.1080/00016489.2022.2118371. Epub 2022 Sep 10.
Primary ciliary dyskinesia (PCD) causes impaired mucociliary clearance and results in chronic pulmonary and sinonasal symptoms.
To study the CT imaging features of paranasal sinuses in children with PCD.
17 PCD patients ranged from 4 to 13 years, a mean age of 7.9 ± 3.3 years, were included in the final analysis. Patients with non-PCD chronic rhinosinusitis (CRS) who accepted maxillary balloon catheter dilation were included in the control group. Paranasal sinuses CT scans were scored according to the Lund-Mackay staging system. The correlation between age and Lund-Mackay score was analyzed.
100% (17/17) had rhinosinusitis, 52.9% (9/17) had lung consolidation, 64.7% (11/17) had atelectasis, 35.3% (6/17) had bronchiectasis, and 47.1% (8/17) had a history of neonatal respiratory distress. The mean Lund-Mackay score of PCD patients was 14.2 ± 3.1, that of non-PCD CRS patients was 14.6 ± 5.5, the difference was not significant ( = .79). There was a significant inverse correlation between age and Lund-Mackay score in PCD patients ( = -0.530, = .029) but not in non-PCD CRS patients ( = -0.168, = .519).
Radiographic severity of rhinosinusitis in PCD patients was similar to the control population but decreased with age.
First time to propose radiographic severity of rhinosinusitis in pediatric patients with PCD might decrease with age.
原发性纤毛运动障碍（PCD）可导致黏液纤毛清除功能受损，引起慢性肺部和鼻旁窦症状。
研究 PCD 患儿鼻旁窦的 CT 成像特征。
最终分析纳入了 17 名年龄 4 至 13 岁（平均年龄 7.9±3.3 岁）的 PCD 患者。纳入了接受上颌球囊导管扩张的非 PCD 慢性鼻-鼻窦炎（CRS）患者作为对照组。根据 Lund-Mackay 分期系统对鼻旁窦 CT 扫描进行评分。分析年龄与 Lund-Mackay 评分之间的相关性。
100%（17/17）的患者有鼻-鼻窦炎，52.9%（9/17）的患者有肺部实变，64.7%（11/17）的患者有肺不张，35.3%（6/17）的患者有支气管扩张，47.1%（8/17）的患者有新生儿呼吸窘迫病史。PCD 患者的平均 Lund-Mackay 评分为 14.2±3.1，非 PCD CRS 患者为 14.6±5.5，差异无统计学意义（ = .79）。在 PCD 患者中，年龄与 Lund-Mackay 评分呈显著负相关（ = -0.530， = .029），而非 PCD CRS 患者中无相关性（ = -0.168， = .519）。
PCD 患者的鼻-鼻窦炎放射学严重程度与对照组相似，但随年龄增长而降低。
首次提出 PCD 患儿的鼻-鼻窦炎放射学严重程度可能随年龄增长而降低。
