Seo Hyo-Deok, Lee Eunyoung, Ahn Jiyun, Hahm Jeong-Hoon, Ha Tae-Youl, Lee Dae-Hee, Jung Chang Hwa
Aging and Metabolism Research Group, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, South Korea.
Department of Food Biotechnology, University of Science and Technology, Daejeon, South Korea.
J Food Biochem. 2022 Dec;46(12):e14395. doi: 10.1111/jfbc.14395. Epub 2022 Sep 12.
Codium fragile (C. fragile) is a marine alga with high functional food potential. Recent studies have proven C. fragile extract (CFE) effective against obesity. However, the exact underlying mechanism of CFE's anti-obesity effects remains unclear. Herein, CFE was orally administered to male C57BL/6 mice for 7 weeks, along with a high-fat diet. CFE (100 mg/kg) effectively induced weight loss, lowered serum cholesterol levels, and suppressed adipocyte differentiation in white adipose tissue (WAT). Furthermore, CFE effectively reduced hepatic total triglyceride, cholesterol, and lipid levels, while significantly improving liver size and color. mRNA expression analysis in WAT and liver tissue revealed that CFE significantly suppressed the expression of PPARγ and aP-2 in adipocyte differentiation, and SREBP-1c and FAS in de novo lipogenesis, suggesting that CFE's anti-obesity effect is exerted by gene inhibition. PRACTICAL APPLICATIONS: Research on marine plants with anti-obesity effects has been increasing recently. This study demonstrated that C. fragile extract (CFE) is effective in reducing body weight and suppressing adipocyte differentiation, along with the improvement of fatty liver in mice fed with a high-fat diet (HFD). The anti-obesity effect of CFE was exhibited by the down-regulation of adipogenesis and lipogenesis, respectively. Based on these results, C. fragile could be useful, not only to effectively combat obesity but also in improving obesity-induced liver dysfunction.
鼠尾藻是一种具有高功能性食品潜力的海洋藻类。最近的研究已证明鼠尾藻提取物（CFE）对肥胖有效。然而，CFE抗肥胖作用的确切潜在机制仍不清楚。在此，将CFE口服给予雄性C57BL/6小鼠7周，同时给予高脂饮食。CFE（100mg/kg）有效地诱导体重减轻，降低血清胆固醇水平，并抑制白色脂肪组织（WAT）中的脂肪细胞分化。此外，CFE有效地降低了肝脏总甘油三酯、胆固醇和脂质水平，同时显著改善了肝脏大小和颜色。WAT和肝脏组织中的mRNA表达分析表明，CFE显著抑制脂肪细胞分化中PPARγ和aP-2的表达，以及从头脂肪生成中SREBP-1c和FAS的表达，表明CFE的抗肥胖作用是通过基因抑制发挥的。实际应用：最近对具有抗肥胖作用的海洋植物的研究不断增加。本研究表明，CFE对高脂饮食（HFD）喂养的小鼠具有减轻体重、抑制脂肪细胞分化以及改善脂肪肝的作用。CFE的抗肥胖作用分别通过脂肪生成和脂质生成的下调来体现。基于这些结果，鼠尾藻不仅可有效对抗肥胖，还可改善肥胖引起的肝功能障碍。
