HeLa细胞中甲氨蝶呤耐药性早期发展阶段的染色体畸变
Chromosomal aberrations in early stages of development of methotrexate resistance in HeLa cells.
作者信息
Delinassios J G, Talieri M J
出版信息
Exp Cell Biol. 1987;55(2):69-73. doi: 10.1159/000163400.
PMID:3609440
Abstract
High incidence of dicentrics, rings, double rings, acentric rod-like fragments and double minutes in polyploid cells during the early stages of development of methotrexate resistance in HeLa cells suggests that hypertetraploid cells are precursors of cells with higher resistance levels.
摘要
在HeLa细胞对甲氨蝶呤耐药性发展的早期阶段，多倍体细胞中双着丝粒、环状染色体、双环染色体、无着丝粒杆状片段和双微体的高发生率表明，超四倍体细胞是具有更高耐药水平细胞的前体。
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