双侧丘脑和单侧丘脑胶质瘤中的表皮生长因子受体第20外显子插入：2例报告及文献综述 - Suppr

EGFR Exon 20 Insertion in Bithalamic and Unithalamic Glioma: A Report of 2 Cases and Literature Review.

作者信息

Hein Ashley L, Cathcart Sahara J, Cushman-Vokoun Allison, Shonka Nicole A, Abromowitch Minnie, Punsoni Michael, Chen Jie

机构信息

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

出版信息

J Neuropathol Exp Neurol. 2022 Oct 18;81(11):943-946. doi: 10.1093/jnen/nlac080.

DOI:10.1093/jnen/nlac080

PMID:36094585

Abstract

摘要

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EGFR Exon 20 Insertion in Bithalamic and Unithalamic Glioma: A Report of 2 Cases and Literature Review.双侧丘脑和单侧丘脑胶质瘤中的表皮生长因子受体第20外显子插入：2例报告及文献综述

J Neuropathol Exp Neurol. 2022 Oct 18;81(11):943-946. doi: 10.1093/jnen/nlac080.

Precision Medicine in Pediatric Bithalamic Glioma: Significance of the EGFR exon 20 Insertion Mutation.小儿双侧丘脑胶质瘤的精准医学：表皮生长因子受体（EGFR）第20外显子插入突变的意义

World Neurosurg. 2021 May;149:271-273. doi: 10.1016/j.wneu.2021.03.009.

Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition.小儿双侧丘脑胶质瘤具有独特的表观遗传特征和高频的 EGFR 外显子 20 插入，从而可能对靶向激酶抑制敏感。

Acta Neuropathol. 2020 Jun;139(6):1071-1088. doi: 10.1007/s00401-020-02155-5. Epub 2020 Apr 17.

EGFR exon 20 insertion mutation in Japanese lung cancer.日本肺癌中的表皮生长因子受体（EGFR）第20外显子插入突变

Lung Cancer. 2007 Dec;58(3):324-8. doi: 10.1016/j.lungcan.2007.06.024. Epub 2007 Aug 7.

[Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer].[非小细胞肺癌中表皮生长因子受体第20外显子插入突变的研究与进展]

Zhongguo Fei Ai Za Zhi. 2020 Feb 20;23(2):118-126. doi: 10.3779/j.issn.1009-3419.2020.02.07.

Prevalence, clinicopathologic characteristics, and molecular associations of EGFR exon 20 insertion mutations in East Asian patients with lung adenocarcinoma.东亚肺腺癌患者中表皮生长因子受体（EGFR）第20外显子插入突变的患病率、临床病理特征及分子关联

Ann Surg Oncol. 2014 Dec;21 Suppl 4:S490-6. doi: 10.1245/s10434-013-3452-1. Epub 2014 Jan 14.

Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea.韩国晚期非小细胞肺癌中 EGFR 外显子 20 插入突变的临床结局。

Cancer Res Treat. 2019 Apr;51(2):623-631. doi: 10.4143/crt.2018.151. Epub 2018 Jul 23.

EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics.肺腺癌中 EGFR 外显子 20 插入突变：流行率、分子异质性和临床病理特征。

Mol Cancer Ther. 2013 Feb;12(2):220-9. doi: 10.1158/1535-7163.MCT-12-0620. Epub 2013 Jan 31.

[The research status and development trend of EGFR gene exon 20 insertion mutant non-small cell lung cancer].表皮生长因子受体（EGFR）基因第20外显子插入突变型非小细胞肺癌的研究现状与发展趋势

Zhonghua Zhong Liu Za Zhi. 2020 Jan 23;42(1):22-29. doi: 10.3760/cma.j.issn.0253-3766.2020.01.003.

A Case of Primary Resistance to Geﬁtinib due to Novel Deletion-Insertion Mutation of EGFR Exon 19 in NSCLC.非小细胞肺癌中因表皮生长因子受体第19外显子发生新型缺失-插入突变导致对吉非替尼原发性耐药1例

J Thorac Oncol. 2019 Jun;14(6):e117-e119. doi: 10.1016/j.jtho.2019.01.033.

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EGFR Exon 20 Insertion in Bithalamic and Unithalamic Glioma: A Report of 2 Cases and Literature Review.

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