Epicoccanes A-D, Four Oxidative Dimers of Pyrogallol Analogues from .

Epicoccanes A-D (-) are four novel metabolites of an endophytic fungus . Their distinct unprecedented structures are hypothesized as oxidative dimers of pyrogallol analogues. Compounds and possess a novel spirobicyclo[3.2.1]octane-6,1'-cyclopentane or -cyclohexane core skeleton. Compound is of a unique cage-like pentacyclic system, which unusually contained three continuous spiro-carbons. Compound is a highly rearranged dimer with five contiguous chiral centers. The absolute structures of and were deduced by electronic circular dichroism (ECD) calculations, and those of and were determined by X-ray crystallography. Compounds and showed potential antiliver fibrosis activity.