表棒曲霉素A-D，来自一株定殖于虫草的黑附球菌的多硫二氧哌嗪类化合物。

Epicoccins A-D, epipolythiodioxopiperazines from a Cordyceps-colonizing isolate of Epicoccum nigrum.

作者信息

Zhang Yonggang, Liu Shuchun, Che Yongsheng, Liu Xingzhong

机构信息

Key Laboratory of Systematic Mycology and Lichenology, and Center for Bio-Energy and Industrial Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China.

出版信息

J Nat Prod. 2007 Sep;70(9):1522-5. doi: 10.1021/np070239u. Epub 2007 Aug 22.

DOI:10.1021/np070239u

PMID:17711348

Abstract

Epicoccins A-D (1-4), four unique epipolythiodioxopiperazines possessing unusual sulfur bridges, have been isolated from cultures of a Cordyceps-colonizing isolate of Epicoccum nigrum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative and absolute configuration of epicoccin A (1) was established by single-crystal X-ray diffraction analysis. Epicoccin A (1) showed modest antimicrobial activity.

摘要

表棒曲霉素A-D（1-4）是从一株寄生于虫草的黑附球菌分离物的培养物中分离得到的四种独特的含不寻常硫桥的表多硫代二氧哌嗪。这些化合物的结构主要通过对其核磁共振光谱数据的分析来确定。表棒曲霉素A（1）的相对和绝对构型通过单晶X射线衍射分析得以确定。表棒曲霉素A（1）显示出适度的抗菌活性。