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由......引起的复发性人工关节感染:病例报告及文献复习。

A recurrent prosthetic joint infection caused by : case report and literature review.

机构信息

Bacteriology and Hygiene Department, Teaching Hospital of Rennes, 2 rue Henri-Le-Guilloux, 35033 Rennes, France.

CRIOGO Great West Reference Centers for Complex Bone and Joint Infections (CRIOGO), Rennes, France.

出版信息

J Med Microbiol. 2022 Sep;71(9). doi: 10.1099/jmm.0.001580.

Abstract

Prosthetic knee joint infection caused by is uncommon and only one case of recurrent infection has previously been described. Here, we describe the case of a 77-year-old male patient who was admitted to the teaching hospital of Rennes (France) with bilateral and nocturnal gonalgia evolving for 1 month. He had bilateral knee prosthesis 10 years ago, and a history of large B-cell lymphoma in remission. A diagnosis of infective endocarditis, with prosthetic knee infection, was made, with positive cultures of synovial fluids and blood; colonies of were identified by MALDI-TOF MS. Initial treatment involved debridement, implant retention surgery and intravenous amoxicillin (12 g day) for 6 weeks with gentamicin 3 mg kg day added for the first 4 days. One year later, a second episode of infection occurred, suggesting a recurrence or reinfection due to the same bacterial species. The patient was finally cured after a two-stage exchange with a cemented articulated spacer and a 3 month course of amoxicillin (12 g day, iv). Different characteristics of infection were discussed, with a review of all cases of prosthetic joint infections caused by species. This case highlights the need for a long-term survey of patients, and a good knowledge of their environment to avoid any risk of reinfection.

摘要

由 引起的人工膝关节感染并不常见,先前仅描述过一例复发性感染。在此,我们描述了一位 77 岁男性患者的病例,他因双侧夜间膝关节痛入院,病史 1 个月。10 年前他接受了双侧膝关节假体置换术,且处于缓解期的大型 B 细胞淋巴瘤病史。诊断为感染性心内膜炎合并人工膝关节感染,关节液和血液的培养均为阳性;MALDI-TOF MS 鉴定出 为优势菌。初始治疗包括清创、保留假体手术和静脉滴注阿莫西林(12g/天)6 周,前 4 天加用庆大霉素 3mg/kg/天。1 年后,再次发生 感染,提示为同一细菌的复发或再感染。经过二期关节置换术(带水泥固定关节间隔器)和 3 个月的阿莫西林(12g/天,iv)治疗后,患者最终痊愈。我们讨论了 感染的不同特征,并回顾了所有由 引起的人工关节感染病例。该病例强调了需要对患者进行长期监测,并充分了解其环境以避免任何再感染的风险。

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