各种日抛型接触镜的与解相关的体外去湿行为。

SIGNIFICANCE

The dewetting process of contact lenses (CLs) is a result of material and solution properties as well as environmental factors. This article describes an investigational approach to observe and describe dewetting characteristics of different CL material and solution combinations.

PURPOSE

This study aimed to determine the in vitro dewetting characteristics of various daily disposable CLs that were assessed using a noninvasive keratograph dewetting procedure (noninvasive keratograph dry-up time). In vitro dewetting data of the same CL materials soaked in saline solution and artificial tear solution (ATS) were measured to determine additional dewetting characteristics.

METHODS

Noninvasive keratograph dry-up time was measured for six different soft CL materials and three different test conditions, in their specific blister solution, after exposure to saline and an ATS. Twenty CLs of each solution/material combination were assessed after an 8-hour soaking, during a 180-second dewetting observation, and the results were expressed by area under the curve values.

RESULTS

Fastest dewetting occurred for all materials when measured out of saline, indicated by the highest averaged area under the curve value of 9243.3 ± 38.3 over all lens materials. Slower dewetting was detected for all materials when measured out of their specific blister solution (7755.9 ± 37.1) and out of ATS (7988.8 ± 40.0). Intragroup results were statistically significantly different for all solutions showing the smallest differences within the ATS group ( P < .001, Kruskal-Wallis test).

CONCLUSIONS

A pure saline thin film is not an ideal representation of a complex tear film layer of a healthy human because it lacks any evaporative protection by a lipid layer. The use of an ATS, which more likely mimics the natural tear film, allowed in this experimental in vitro project to decrease the gap to the in vivo field. In vitro dewetting information in connection with the blister solution allows only a theoretical conclusion about the initial lens wear after lens insertion.

意义

隐形眼镜（CL）的去湿过程是材料和溶液特性以及环境因素的结果。本文描述了一种研究方法，用于观察和描述不同 CL 材料和溶液组合的去湿特性。

目的

本研究旨在使用非侵入性角膜描记仪去湿程序（非侵入性角膜描记仪干燥时间）评估各种日戴型 CL 的体外去湿特性。测量相同 CL 材料在盐溶液和人工泪液（ATS）中的浸泡后的体外去湿数据，以确定其他去湿特性。

方法

在其特定的泡罩溶液中测量了六种不同的软 CL 材料和三种不同的测试条件下的非侵入性角膜描记仪干燥时间，在暴露于盐溶液和 ATS 后。评估了每种溶液/材料组合的 20 个 CL，在 180 秒的去湿观察过程中浸泡 8 小时后，结果以曲线下面积值表示。

结果

当从盐溶液中测量时，所有材料的去湿速度最快，所有镜片材料的平均曲线下面积值最高，为 9243.3±38.3。当从其特定的泡罩溶液（7755.9±37.1）和 ATS（7988.8±40.0）中测量时，所有材料的去湿速度较慢。所有溶液的组内结果均有统计学显著差异，ATS 组内差异最小（P<0.001，Kruskal-Wallis 检验）。