泛素家族蛋白与磷脂的缀合。
Conjugation of the ubiquitin family proteins to phospholipids.
机构信息
Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
Autophagy. 2023 Apr;19(4):1361-1362. doi: 10.1080/15548627.2022.2123637. Epub 2022 Sep 20.
Conjugation of Atg8-family proteins to phosphatidylethanolamine (PE) is important for autophagosome formation. PE conjugation has been thought to be specific to Atg8 among the ubiquitin-family proteins. However, this dogma has not been experimentally verified. Our recent study revealed that ubiquitin is also conjugated to PE on endosomes and the vacuole (or lysosomes). Other ubiquitin-like proteins, such as NEDD8 and ISG15, also covalently bind to phospholipids. We propose that conjugation to phospholipids could be a common feature of the ubiquitin family.
Atg8 家族蛋白与磷脂酰乙醇胺（PE）的缀合对于自噬体的形成很重要。PE 缀合被认为是泛素家族蛋白中特有的 Atg8。然而，这一教条尚未经过实验验证。我们最近的研究表明，泛素也在内体和液泡（或溶酶体）上与 PE 缀合。其他泛素样蛋白，如 NEDD8 和 ISG15，也与磷脂共价结合。我们提出，与磷脂的缀合可能是泛素家族的一个共同特征。
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