Department of Neurology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey.
Mult Scler Relat Disord. 2022 Dec;68:104149. doi: 10.1016/j.msard.2022.104149. Epub 2022 Aug 28.
Epstein-Barr virus is considered a risk factor for the development of multiple sclerosis, and recent findings reveal infected plasma -cells in meningeal ectopic lymphoid deposits. Activation of the dormant virus could be responsible for the multiple sclerosis exacerbation AIMS: To compare Epstein-Barr nuclear IgG (EBNA IgG) titer in newly diagnosed treatment-naive multiple sclerosis patients regarding the diagnoses date, clinical and radiological activity.
Treatment-naive multiple sclerosis patients were divided into two groups according to Poser (late group) and McDonald2017(early group) diagnostic criteria. EBNA IgG, EDSS, physical (Timed 25 Foot Walk test, Nine-hole Peg test), and cognitive tests (Brief International Cognitive Assessment for Multiple Sclerosis) were done before the methylprednisolone infusion. The lesion location was evaluated by an MRI. Myelitis was considered a severe attack, and optic neuritis a mild relapse.
In total, 69 patients were enrolled. 44 (63.8%) of them were diagnosed by McDonald2017, and 25 (36.2%) were diagnosed with Poser criteria. There was a significant difference (p = 0.049) between the EBNA IgG titer of the late (median:238 U/ml, IQR: 154-362) and early (median: 154 U/ml, IQR:100.25-293.25). Severe relapse, having a spinal cord lesion, and not being treated with methylprednisolone was associated with higher EBNA IgG titer.
Study results show that EBNA IgG was significantly associated with disease activity regarding relapse severity and lesion location and could be a potential biomarker for predicting disease exacerbation.
爱泼斯坦-巴尔病毒（Epstein-Barr virus）被认为是多发性硬化症发展的一个风险因素，最近的研究结果显示脑膜异位淋巴组织中有受感染的浆细胞。休眠病毒的激活可能是多发性硬化症恶化的原因。
比较新诊断的未经治疗的多发性硬化症患者中，根据爱泼斯坦-巴尔核 IgG（EBNA IgG）滴度与诊断日期、临床和影像学活动的关系。
根据 Poser（晚期组）和 McDonald2017（早期组）的诊断标准，将未经治疗的多发性硬化症患者分为两组。在甲基强的松龙输注前进行 EBNA IgG、EDSS、躯体（计时 25 英尺步行测试、九孔钉测试）和认知测试（多发性硬化症简明国际认知评估）。通过 MRI 评估病变位置。髓炎被认为是严重发作，视神经炎为轻度复发。
共纳入 69 例患者。其中 44 例（63.8%）根据 McDonald2017 诊断，25 例（36.2%）根据 Poser 标准诊断。晚期（中位数：238 U/ml，IQR：154-362）和早期（中位数：154 U/ml，IQR：100.25-293.25）EBNA IgG 滴度之间存在显著差异（p=0.049）。严重复发、脊髓病变和未接受甲基强的松龙治疗与较高的 EBNA IgG 滴度相关。
研究结果表明，EBNA IgG 与疾病活动度显著相关，与复发严重程度和病变部位有关，可能是预测疾病恶化的潜在生物标志物。
