University of Texas Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390, USA.
University of Texas Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390, USA.
Foot Ankle Clin. 2022 Sep;27(3):655-670. doi: 10.1016/j.fcl.2022.02.004. Epub 2022 Aug 10.
Severe diabetic foot infections (DFI) are both limb threatening and life threatening and associated with negative impact on health-related quality of life. Most severe DFIs require surgical intervention, and the goal of treatment should be preservation of limb function in addition to eradication of infection. Minor amputations are required in approximately 40% and major amputations in approximately 20% of patients. Significant risk factors for lower extremity amputation included male gender, smoking, previous amputation, osteomyelitis, peripheral artery disease, retinopathy, severe infections, gangrene, neuroischemic diabetic foot infections, leukocytosis, positive wound cultures, and isolation of gram-negative bacteria.
严重的糖尿病足感染（DFI）不仅会威胁肢体，还会威胁生命，并对健康相关生活质量产生负面影响。大多数严重的 DFI 需要手术干预，治疗的目标除了消除感染外，还应保留肢体功能。大约 40%的患者需要进行小截肢，大约 20%的患者需要进行大截肢。下肢截肢的显著危险因素包括男性、吸烟、既往截肢、骨髓炎、外周动脉疾病、视网膜病变、严重感染、坏疽、神经缺血性糖尿病足感染、白细胞增多、伤口培养阳性和革兰氏阴性菌的分离。
