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Endogenous serotonin release from rat cerebellar slices.

作者信息

Velazquez A, Beas-Zarate C, Feria-Velasco A

出版信息

Gen Pharmacol. 1987;18(4):445-8. doi: 10.1016/0306-3623(87)90106-6.

DOI:10.1016/0306-3623(87)90106-6
PMID:3609700
Abstract

Endogenous serotonin (5-HT) content in cerebellar slices and in the incubation medium was measured before and after depolarizing stimulus with high-K+ concentration in the medium. Small amount of 5-HT was spontaneously released from tissue slices incubated in low-K+ and Ca2+-free medium. A significant increase of endogenous 5-HT release was obtained after depolarizing stimulus with high-K+ plus Ca2+ in the medium. It is suggested that the endogenous 5-HT release in cerebellum induced by depolarizing stimuli is a Ca2+-dependent phenomenon.

摘要

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