Du Yan, Wu Jing, Tian Yange, Zhang Lanxi, Zhao Peng, Li Jiansheng
Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province and Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou, China.
Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou, China.
Biomed Chromatogr. 2023 Jan;37(1):e5507. doi: 10.1002/bmc.5507. Epub 2022 Sep 22.
Exercise training is the cornerstone component of pulmonary rehabilitation, which results in symptom-reducing, psychosocial, and health economic benefits for chronic obstructive pulmonary disease (COPD) patients. However, the potential mechanisms of its action are poorly understood. This study conducted serum metabolomics using ultra-high performance liquid chromatography-Q-Exactive tandem mass spectrometry to determine the metabolic changes in COPD rats, and the effects of exercise training on improvement in COPD were further investigated. Twelve differential metabolites-which are primarily related to tryptophan metabolism, sphingolipid metabolism, glycerophospholipid metabolism, riboflavin metabolism, pantothenate and CoA biosynthesis, and lysine degradation-were identified in relation to COPD. After the intervention of exercise training, the levels of most metabolites were restored, and the changes in five metabolites were statistically significant, which suggested that exercise training provided effective protection against COPD and might play its role by rebalancing disordered metabolism pathways. This work enhanced our comprehension of the protective mechanism of exercise training on COPD.
运动训练是肺康复的核心组成部分，它能为慢性阻塞性肺疾病（COPD）患者带来减轻症状、改善心理社会状况以及健康经济效益。然而，其作用的潜在机制尚不清楚。本研究采用超高效液相色谱-Q-Exactive串联质谱法进行血清代谢组学分析，以确定COPD大鼠的代谢变化，并进一步研究运动训练对改善COPD的影响。与COPD相关的12种差异代谢物被鉴定出来，它们主要与色氨酸代谢、鞘脂代谢、甘油磷脂代谢、核黄素代谢、泛酸和辅酶A生物合成以及赖氨酸降解有关。运动训练干预后，大多数代谢物水平恢复，5种代谢物的变化具有统计学意义，这表明运动训练对COPD提供了有效的保护，可能通过重新平衡紊乱的代谢途径发挥作用。这项工作加深了我们对运动训练对COPD保护机制的理解。
