Department of Chemistry, School of Science, China Pharmaceutical University Nanjing, 211198, P. R. China.
Product Development Centre, Yichang Humanwell Pharmaceutical Co., Ltd, Yichang, 443005, P. R. China.
Chem Commun (Camb). 2022 Oct 4;58(79):11095-11098. doi: 10.1039/d2cc04064f.
This work demonstrates for the first time that a photochromic metal organic framework (pMOF) can be employed as a promising class of NIR-II photothermal material based on the photoinduced donor-acceptor intermolecular charge transfer process. After further surface-modification, such UV-activated pMOF-a nanoparticles allow the strong inhibition of 4T1 cancer cells under 1064 nm laser irradiation.
这项工作首次证明，光致变色金属有机骨架（pMOF）可以作为一类有前途的近红外二区光热材料，基于光诱导给体-受体分子间电荷转移过程。进一步的表面修饰后，这种紫外光激活的 pMOF-a 纳米粒子可以在 1064nm 激光照射下强烈抑制 4T1 癌细胞。
