Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Department of Ophthalmology Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China.
Aging (Albany NY). 2022 Sep 12;14(18):7408-7415. doi: 10.18632/aging.204276.
As the leading cause of cancer-related death worldwide, non-small-cell lung cancer (NSCLC) is still in need of improved therapeutic strategies. CircKIF4A has been found to be involved in the progression of multiple cancers while its role in NSCLC remains unclear. To investigate the functions of circKIF4A, we assessed the expression of circKIF4A in NSCLC cells and tissues and performed experiments to determine the detailed functions of circKIF4A in NSCLC, including migration and proliferation. We found CircKIF4A expressed more heavily in the cells and tissues of NSCLC patients, and functional studies showed that inhibition of circKIF4A reduced NSCLC cells metastasis and proliferation. Furthermore, we seek to identify the underlying regulatory effect of circKIF4A in NSCLC. Studies revealed that circKIF4A sponged miR-1238 to promote NSCLC progression by up-regulating claudin14 (CLDN14) expression. In conclusion, circKIF4A is a potential diagnostic and therapeutic target in the circKIF4A/miR-1238/CLDN14 axis that plays an important role in NSCLC progression.
作为全球癌症相关死亡的主要原因，非小细胞肺癌（NSCLC）仍需要改进的治疗策略。已经发现 CircKIF4A 参与了多种癌症的进展，但其在 NSCLC 中的作用尚不清楚。为了研究 circKIF4A 的功能，我们评估了 NSCLC 细胞和组织中 circKIF4A 的表达，并进行了实验以确定 circKIF4A 在 NSCLC 中的详细功能，包括迁移和增殖。我们发现 CircKIF4A 在 NSCLC 患者的细胞和组织中表达更为丰富，功能研究表明抑制 circKIF4A 可降低 NSCLC 细胞的转移和增殖。此外，我们试图确定 circKIF4A 在 NSCLC 中的潜在调节作用。研究表明，circKIF4A 通过上调 Claudin14（CLDN14）的表达来吸收 miR-1238，从而促进 NSCLC 的进展。总之，circKIF4A 是 circKIF4A/miR-1238/CLDN14 轴中的一个潜在的诊断和治疗靶点，在 NSCLC 进展中发挥着重要作用。
