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Response to: "Utility of endogenous 4β-hydroxycholesterol as a biomarker to assess cytochrome P 450 3A (CYP3A) activity: not quite ready for prime time".

作者信息

Kvitne Kine Eide, Hole Kristine, Molden Espen, Robertsen Ida

机构信息

Section for Pharmacology, Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Blindern, P.O. Box 1068, 0316, Oslo, Norway.

Center for Psychopharmacology, Diakonhjemmet Hospital, Oslo, Norway.

出版信息

Eur J Clin Pharmacol. 2022 Nov;78(11):1865-1866. doi: 10.1007/s00228-022-03387-y. Epub 2022 Sep 13.

DOI:10.1007/s00228-022-03387-y
PMID:36098754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9546967/
Abstract
摘要

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Eur J Clin Pharmacol. 2022 Aug;78(8):1289-1299. doi: 10.1007/s00228-022-03336-9. Epub 2022 Jun 1.
2
Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite 4β-Hydroxycholesterol-an Interaction Study in Healthy Volunteers.摄入柚子汁对健康志愿者体内内源性 CYP3A4 代谢物 4β-羟基胆固醇血清水平的影响——一项相互作用研究。
AAPS J. 2019 Apr 24;21(4):58. doi: 10.1208/s12248-019-0330-1.
3
4β-Hydroxycholesterol as an Endogenous Biomarker for CYP3A Activity: Literature Review and Critical Evaluation.4β-羟基胆固醇作为 CYP3A 活性的内源性生物标志物：文献综述与批判性评价。
J Clin Pharmacol. 2019 May;59(5):611-624. doi: 10.1002/jcph.1391. Epub 2019 Feb 12.
4
Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults.肥胖青少年咪达唑仑清除率高于病态肥胖成年人。
Clin Pharmacokinet. 2018 May;57(5):601-611. doi: 10.1007/s40262-017-0579-4.
5
Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients.病态肥胖及减肥手术患者中咪达唑仑和CYP3A介导的代谢物1-羟基咪达唑仑的半生理药代动力学模型
CPT Pharmacometrics Syst Pharmacol. 2016 Jan;5(1):20-30. doi: 10.1002/psp4.12048. Epub 2015 Dec 18.
6
Appropriate phenotyping procedures for drug metabolizing enzymes and transporters in humans and their simultaneous use in the "cocktail" approach.人类药物代谢酶和转运体的适当表型分析程序及其在“鸡尾酒”法中的同时应用。
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