Department of Urology, Suzhou Hospital of Anhui Medical University, Suzhou, China.
Department of Urology, Lu'an Hospital of Anhui Medical University, Lu'an, China.
J Clin Lab Anal. 2022 Oct;36(10):e24700. doi: 10.1002/jcla.24700. Epub 2022 Sep 13.
The purpose of the study was to evaluate the diagnostic significance of two new and a few clinical markers for prostate cancer (PCa) at various prostate volumes (PV).
The study subjects were divided into two groups. Among them, there were 70 cases in the PV ≤30 ml group (benign prostatic hyperplasia [BPH]: 32 cases, PCa: 38 cases) and 372 cases in the PV > 30 ml group (BPH: 277 cases, PCa: 95 cases). SPSS 26.0 and GraphPad Prism 8.0 were used to construct their receiver operating characteristic (ROC) curves for diagnosing PCa and calculating their area under the ROC curve (AUC).
In the PV ≤30 ml group, the diagnostic parameters based on prostate-specific antigen (PSA) had a decreased diagnostic significance for PCa. In the PV > 30 ml group, PSAD (AUC = 0.709), AVR (AVR = Age/PV, AUC = 0.742), and A-PSAD (A-PSAD = Age×PSA/PV, AUC = 0.736) exhibited moderate diagnostic significance for PCa, which was better than PSA-AV (AUC = 0.672), free PSA (FPSA, AUC = 0.509), total PSA (TPSA, AUC = 0.563), (F/T) PSA (AUC = 0.540), and (F/T)/PSAD (AUC = 0.663). Compared with AVR, A-PSAD exhibited similar diagnostic significance for PCa, but higher than PSA density (PSAD).
Choosing appropriate indicators for different PVs could contribute to the early screening and diagnosis of PCa. The difference in the diagnostic value of two new indicators (A-PSAD and AVR), and PSAD for PCa may require further validation by increasing the sample size.
本研究旨在评估两种新的和几种临床标志物在不同前列腺体积（PV）下对前列腺癌（PCa）的诊断意义。
研究对象分为两组。其中，PV≤30ml 组 70 例（良性前列腺增生[BPH]：32 例，PCa：38 例），PV＞30ml 组 372 例（BPH：277 例，PCa：95 例）。采用 SPSS 26.0 和 GraphPad Prism 8.0 构建受试者工作特征（ROC）曲线，用于诊断 PCa，并计算 ROC 曲线下面积（AUC）。
在 PV≤30ml 组中，基于前列腺特异性抗原（PSA）的诊断参数对 PCa 的诊断意义降低。在 PV＞30ml 组中，PSAD（AUC=0.709）、AVR（AVR=Age/PV，AUC=0.742）和 A-PSAD（A-PSAD=Age×PSA/PV，AUC=0.736）对 PCa 具有中等诊断意义，优于 PSA-AV（AUC=0.672）、游离前列腺特异性抗原（FPSA，AUC=0.509）、总前列腺特异性抗原（TPSA，AUC=0.563）、（F/T）PSA（AUC=0.540）和（F/T）/PSAD（AUC=0.663）。与 AVR 相比，A-PSAD 对 PCa 的诊断意义相似，但高于 PSAD。
选择不同 PV 下的合适指标有助于 PCa 的早期筛查和诊断。两种新指标（A-PSAD 和 AVR）和 PSAD 对 PCa 的诊断价值的差异可能需要通过增加样本量进一步验证。
