Horváth E J, Varga B, Zsolnai B, Stark E
Gynecol Obstet Invest. 1987;23(4):261-6. doi: 10.1159/000298870.
The effects of the beta 2-adrenergic agonist hexoprenaline were studied on the progesterone production of rat and human corpora lutea and compared to hCG-induced hormone production. Human corpora lutea were obtained from healthy patients, rat corpora lutea were harvested on day 6 of pseudopregnancy. Corpora lutea were digested by trypsin and homogeneous luteal cell suspension (6 X 10(5) cells/ml) was incubated for 2 h. Hexoprenaline and hCG were added to the medium and progesterone production was measured by RIA. Hexoprenaline or hCG dose-dependently increased the progesterone production of rat luteal cells and of human cells in mid- and late luteal phase. Moreover, hexoprenaline further increased the hCG-induced hormone production. The stimulatory effect of hexoprenaline could be prevented by propranolol. It is supposed that beta 2-adrenergic stimulation induces an increase in progesterone production of luteal cells and potentiates the effects of gonadotropic hormones.
研究了β2 - 肾上腺素能激动剂海索那林对大鼠和人黄体孕酮生成的影响，并与hCG诱导的激素生成进行比较。人黄体取自健康患者，大鼠黄体于假孕第6天获取。黄体用胰蛋白酶消化，将均匀的黄体细胞悬液（6×10⁵个细胞/ml）孵育2小时。向培养基中加入海索那林和hCG，用放射免疫分析法测定孕酮生成。海索那林或hCG剂量依赖性地增加大鼠黄体细胞以及人黄体中期和晚期细胞的孕酮生成。此外，海索那林进一步增加hCG诱导的激素生成。普萘洛尔可阻止海索那林的刺激作用。据推测，β2 - 肾上腺素能刺激可诱导黄体细胞孕酮生成增加，并增强促性腺激素的作用。
