Department of Medical Cosmetology, Yanbian University Hospital, Yanji, China.
Department of Dermatology, Yanbian University Hospital, Yanji, China.
J Cosmet Dermatol. 2022 Dec;21(12):6767-6775. doi: 10.1111/jocd.15384. Epub 2022 Sep 30.
Rosacea is a chronic inflammatory skin disease affecting the face, and the current treatment effect is not satisfactory. Based on the photomodulation of optimal pulse technology (OPT), we developed a novel treatment mode, namely, advanced OPT with low energy, three pulses, and long pulse width (AOPT-LTL).
We aimed to explore the feasibility and underlying molecular mechanisms of AOPT-LTL treatment in a rosacea-like mouse model. Furthermore, we evaluated the safety and efficacy in patients with erythematotelangiectatic rosacea (ETR).
Morphological, histological, and immunohistochemical analyses were used to investigate the efficacy and mechanisms of AOPT-LTL treatment in the LL-37-induced rosacea-like mouse model. Moreover, 23 patients with ETR were included and received different times of treatment at intervals of 2 weeks depending on the severity of their condition. The treatment effect was assessed by comparing clinical photographs at baseline, 1 week, and 3 months after treatment, combined with the red value, GFSS, and CEA scores.
After the AOPT-LTL treatment of the mice, we observed that the rosacea-like phenotype, inflammatory cell infiltration, and vascular abnormalities were significantly ameliorated, and the expression of the core molecules of rosacea was significantly inhibited. In the clinical study, the AOPT-LTL treatment exerted satisfactory therapeutic effects on erythema and flushing of ETR patients. No serious adverse events were observed.
AOPT-LTL is a safe and effective method for the treatment of ETR.
酒渣鼻是一种影响面部的慢性炎症性皮肤疾病，目前的治疗效果并不理想。基于最佳脉冲技术（OPT）的光调制，我们开发了一种新的治疗模式，即低能量、三脉冲、长脉宽的高级 OPT（AOPT-LTL）。
我们旨在探讨 AOPT-LTL 治疗酒渣鼻样小鼠模型的可行性及其潜在的分子机制。此外，我们评估了其在红斑毛细血管扩张型酒渣鼻（ETR）患者中的安全性和疗效。
采用形态学、组织学和免疫组织化学分析方法，研究 AOPT-LTL 在 LL-37 诱导的酒渣鼻样小鼠模型中的疗效及其机制。此外，纳入 23 例 ETR 患者，根据病情严重程度，间隔 2 周接受不同次数的治疗。通过比较治疗前、治疗后 1 周和 3 个月的临床照片，结合红斑值、GFSS 和 CEA 评分，评估治疗效果。
在 AOPT-LTL 处理小鼠后，我们观察到酒渣鼻样表型、炎症细胞浸润和血管异常明显改善，酒渣鼻的核心分子表达明显受到抑制。在临床研究中，AOPT-LTL 对 ETR 患者的红斑和潮红表现出令人满意的治疗效果。未观察到严重不良事件。
AOPT-LTL 是治疗 ETR 的一种安全有效的方法。
