靶向谱系可塑性克服化疗耐药性。
Targeting lineage plasticity overcomes chemoresistance.
机构信息
Department of Pathology and Tumor Biology, Graduate School of Medicine, Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
出版信息
Cancer Cell. 2022 Sep 12;40(9):905-907. doi: 10.1016/j.ccell.2022.08.020.
PMID:36099886
Abstract
In this issue of Cancer Cell, Wang et al. reveal that chemoresistant muscle-invasive bladder cancer is associated with partial squamous differentiation. Targeting of Cathepsin H overcomes this chemotherapy-induced semi-squamatization and promotes terminal squamous differentiation and tumor suppression.
摘要
在本期《癌细胞》杂志中，Wang 等人揭示了化疗耐药性肌肉浸润性膀胱癌与部分鳞状分化有关。靶向组织蛋白酶 H 可克服这种化疗诱导的半角化，并促进终末鳞状分化和肿瘤抑制。
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