Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia.
Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; School of Psychological Science, University of Western Australia, Perth, Western Australia, Australia.
Behav Brain Res. 2023 Feb 2;437:114108. doi: 10.1016/j.bbr.2022.114108. Epub 2022 Sep 11.
Lifestyle factors such as physical activity and optimal sleep are associated with better cognition and lower levels of Alzheimer's disease (AD) biomarkers, including brain beta-amyloid (Aβ) burden.
We utilised cross-sectional data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study to determine whether self-reported physical activity (measured via the International Physical Activity Questionnaire) moderates the relationship between self-reported sleep (measured via the Pittsburgh Sleep Quality Index), cognition, and brain Aβ.
Participants were 349 community-dwelling cognitively normal older adults (75.3 ± 5.7 years), all of whom underwent comprehensive cognitive assessment. Data from a subset of participants (n = 201) were used for analyses with brain Aβ burden (measured by positron emission tomography) as the outcome.
Physical activity moderated the relationship between sleep duration and episodic memory (β = -0.10, SE =0.03, p = .005), and sleep efficiency and episodic memory (β = -0.09, SE =0.04, p = .011), such that greater amounts of physical activity mitigated the impact of suboptimal sleep duration and efficiency on episodic memory. Physical activity also moderated the relationship between sleep duration and brain Aβ (β = -0.13, SE =0.06, p = .031), and overall sleep quality and brain Aβ (β = 0.13, SE =0.06, p = .027).
Our findings suggest that physical activity may play an important role in the relationship between sleep and cognitive function, and brain Aβ.
生活方式因素，如身体活动和最佳睡眠，与更好的认知能力和更低水平的阿尔茨海默病（AD）生物标志物有关，包括大脑β-淀粉样蛋白（Aβ）负担。
我们利用澳大利亚成像、生物标志物和生活方式（AIBL）研究的横断面数据，确定自我报告的身体活动（通过国际体力活动问卷测量）是否调节了自我报告的睡眠（通过匹兹堡睡眠质量指数测量）、认知和大脑 Aβ 之间的关系。
参与者是 349 名居住在社区的认知正常的老年人（75.3±5.7 岁），他们都接受了全面的认知评估。来自部分参与者（n=201）的数据用于分析，以大脑 Aβ 负担（通过正电子发射断层扫描测量）作为结果。
身体活动调节了睡眠持续时间和情景记忆之间的关系（β=-0.10，SE=0.03，p=0.005），以及睡眠效率和情景记忆之间的关系（β=-0.09，SE=0.04，p=0.011），即更多的身体活动减轻了睡眠持续时间和效率对情景记忆的不利影响。身体活动还调节了睡眠持续时间和大脑 Aβ 之间的关系（β=-0.13，SE=0.06，p=0.031），以及睡眠质量和大脑 Aβ 之间的关系（β=0.13，SE=0.06，p=0.027）。
我们的研究结果表明，身体活动可能在睡眠和认知功能以及大脑 Aβ 之间的关系中发挥重要作用。
