轻度认知障碍中的24小时活动周期行为与灰质体积

24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment.

作者信息

Balbim Guilherme Moraes, Boa Sorte Silva Nárlon C, Falck Ryan S, Kramer Arthur F, Voss Michelle W, Liu-Ambrose Teresa

机构信息

Department of Physical Therapy, The University of British Columbia, Vancouver, British Columbia, Canada.

Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Alzheimers Dement. 2025 Jul;21(7):e70496. doi: 10.1002/alz.70496.

DOI:10.1002/alz.70496

PMID:40693459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12281022/

Abstract

INTRODUCTION

The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume.

METHODS

Cross-sectional study in 110 adults with MCI. Actigraphy assessed 24-HAC behaviors. FreeSurfer quantified GM. Compositional linear regressions and isotemporal substitution determined 24-HAC composition and GM volume associations.

RESULTS

Higher moderate-to-vigorous physical activity (MVPA) relative to remaining behaviors was associated with greater right inferior temporal gyrus volume (ß = 0.30, false-discovery rate (FDR)-corrected-p = 0.030). Higher SB relative to remaining behaviors was associated with lower volume in the same region (ß = -0.45, FDR-corrected-p = 0.015). Reallocating 30 min from SB to MVPA predicted 2.1% greater (ß = 0.06, p < 0.001) and from MVPA to SB predicted 2.8% lower volume (ß = -0.08, p < 0.001).

DISCUSSION

Increasing MVPA at the expense of SB may protect GM in regions prone to Alzheimer's disease-related atrophy.

TRIAL REGISTRATIONS

ClinicalTrials.gov, NCT02926157, NCT02737878, and NCT02669394.

HIGHLIGHTS

The 24-hour behaviors are associated to inferior temporal volume in older adults with mild cognitive impairment (MCI). More moderate-to-vigorous physical activity (MVPA) is linked with greater inferior temporal volume in older adults with MCI. Allocation from sedentary time to MVPA predicts greater inferior temporal volume.

摘要

引言

24小时活动周期（24-HAC）包括身体活动（PA）、久坐行为（SB）和睡眠。轻度认知障碍（MCI）成年人的24-HAC组成与脑健康之间的关系仍未得到充分研究。我们研究了24-HAC组成与灰质（GM）体积之间的关联。

方法

对110名MCI成年人进行横断面研究。活动记录仪评估24-HAC行为。FreeSurfer软件对GM进行量化。成分线性回归和等时替代法确定24-HAC组成与GM体积的关联。

结果

相对于其他行为，较高的中度至剧烈身体活动（MVPA）与右侧颞下回体积增大相关（β = 0.30，错误发现率（FDR）校正后p = 0.030）。相对于其他行为，较高的SB与同一区域的体积减小相关（β = -0.45，FDR校正后p = 0.015）。将30分钟的SB重新分配为MVPA可使体积增加2.1%（β = 0.06，p < 0.001），而将30分钟的MVPA重新分配为SB可使体积减少2.8%（β = -0.08，p < 0.001）。