Balbim Guilherme Moraes, Boa Sorte Silva Nárlon C, Falck Ryan S, Kramer Arthur F, Voss Michelle W, Liu-Ambrose Teresa
Department of Physical Therapy, The University of British Columbia, Vancouver, British Columbia, Canada.
Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada.
Alzheimers Dement. 2025 Jul;21(7):e70496. doi: 10.1002/alz.70496.
The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume.
Cross-sectional study in 110 adults with MCI. Actigraphy assessed 24-HAC behaviors. FreeSurfer quantified GM. Compositional linear regressions and isotemporal substitution determined 24-HAC composition and GM volume associations.
Higher moderate-to-vigorous physical activity (MVPA) relative to remaining behaviors was associated with greater right inferior temporal gyrus volume (ß = 0.30, false-discovery rate (FDR)-corrected-p = 0.030). Higher SB relative to remaining behaviors was associated with lower volume in the same region (ß = -0.45, FDR-corrected-p = 0.015). Reallocating 30 min from SB to MVPA predicted 2.1% greater (ß = 0.06, p < 0.001) and from MVPA to SB predicted 2.8% lower volume (ß = -0.08, p < 0.001).
Increasing MVPA at the expense of SB may protect GM in regions prone to Alzheimer's disease-related atrophy.
ClinicalTrials.gov, NCT02926157, NCT02737878, and NCT02669394.
The 24-hour behaviors are associated to inferior temporal volume in older adults with mild cognitive impairment (MCI). More moderate-to-vigorous physical activity (MVPA) is linked with greater inferior temporal volume in older adults with MCI. Allocation from sedentary time to MVPA predicts greater inferior temporal volume.
24小时活动周期（24-HAC）包括身体活动（PA）、久坐行为（SB）和睡眠。轻度认知障碍（MCI）成年人的24-HAC组成与脑健康之间的关系仍未得到充分研究。我们研究了24-HAC组成与灰质（GM）体积之间的关联。
对110名MCI成年人进行横断面研究。活动记录仪评估24-HAC行为。FreeSurfer软件对GM进行量化。成分线性回归和等时替代法确定24-HAC组成与GM体积的关联。
相对于其他行为，较高的中度至剧烈身体活动（MVPA）与右侧颞下回体积增大相关（β = 0.30，错误发现率（FDR）校正后p = 0.030）。相对于其他行为，较高的SB与同一区域的体积减小相关（β = -0.45，FDR校正后p = 0.015）。将30分钟的SB重新分配为MVPA可使体积增加2.1%（β = 0.06，p < 0.001），而将30分钟的MVPA重新分配为SB可使体积减少2.8%（β = -0.08，p < 0.001）。
以减少SB为代价增加MVPA可能会保护易发生阿尔茨海默病相关萎缩区域的GM。
ClinicalTrials.gov，NCT02926157、NCT02737878和NCT02669394。
24小时行为与轻度认知障碍（MCI）老年人的颞下体积相关。在患有MCI的老年人中，更多的中度至剧烈身体活动（MVPA）与更大的颞下体积相关。从久坐时间分配为MVPA可预测更大的颞下体积。
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