NRF2/KEAP1领域中需要了解的被忽视的重要事实。 - Suppr

Overlooked and valuable facts to know in the NRF2/KEAP1 field.

作者信息

Kopacz Aleksandra, Rojo Ana I, Patibandla Chinmai, Lastra-Martínez Diego, Piechota-Polanczyk Aleksandra, Kloska Damian, Jozkowicz Alicja, Sutherland Calum, Cuadrado Antonio, Grochot-Przeczek Anna

机构信息

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Department of Biochemistry, Medical College, Autonomous University of Madrid (UAM), Madrid, Spain; Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC/UAM), Madrid, Spain; Instituto de Investigación Sanitaria La Paz (IdiPaz), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

出版信息

Free Radic Biol Med. 2022 Nov 1;192:37-49. doi: 10.1016/j.freeradbiomed.2022.08.044. Epub 2022 Sep 12.

DOI:10.1016/j.freeradbiomed.2022.08.044

PMID:36100148

Abstract

摘要

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Overlooked and valuable facts to know in the NRF2/KEAP1 field.NRF2/KEAP1领域中需要了解的被忽视的重要事实。

Free Radic Biol Med. 2022 Nov 1;192:37-49. doi: 10.1016/j.freeradbiomed.2022.08.044. Epub 2022 Sep 12.

Ginsenoside Rb1 regulates neuronal injury and Keap1-Nrf2/ARE signaling pathway in cerebral infarction rats.人参皂苷Rb1对脑梗死大鼠神经元损伤及Keap1-Nrf2/ARE信号通路的调控作用

J Biol Regul Homeost Agents. 2020 May-Jun;34(3):1091-1095. doi: 10.23812/20-143-L-7.

Targeting Keap1 by miR-626 protects retinal pigment epithelium cells from oxidative injury by activating Nrf2 signaling.靶向 Keap1 的 miR-626 通过激活 Nrf2 信号保护视网膜色素上皮细胞免受氧化损伤。

Free Radic Biol Med. 2019 Nov 1;143:387-396. doi: 10.1016/j.freeradbiomed.2019.08.024. Epub 2019 Aug 22.

Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis.kelch样ECH相关蛋白1缺乏对骨骼组织的影响：破骨细胞生成过程中活化T细胞核因子细胞质1减少的机制

FASEB J. 2017 Sep;31(9):4011-4022. doi: 10.1096/fj.201700177R. Epub 2017 May 17.

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.GULP1 调节尿路上皮癌中的 NRF2-KEAP1 信号轴。

Sci Signal. 2020 Aug 18;13(645):eaba0443. doi: 10.1126/scisignal.aba0443.

Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.锌结合触发了 cullin-3 底物衔接蛋白 KEAP1 的构象开关，从而控制转录因子 NRF2。

Toxicol Appl Pharmacol. 2018 Dec 1;360:45-57. doi: 10.1016/j.taap.2018.09.033. Epub 2018 Sep 24.

The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis.癌蛋白 HBXIP 竞争性结合 KEAP1 以激活 NRF2 并增强乳腺癌细胞的生长和转移。

Oncogene. 2019 May;38(21):4028-4046. doi: 10.1038/s41388-019-0698-5. Epub 2019 Jan 28.

Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice.Nrf2 可保护糖尿病模型小鼠的胰岛 β 细胞免受氧化应激和硝化应激的损伤。

Diabetes. 2014 Feb;63(2):605-18. doi: 10.2337/db13-0909. Epub 2013 Nov 1.

Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2.砷感应和核因子红细胞 2 相关因子 2 抑制中 Kelch 样 ECH 相关蛋白 1 的关键半胱氨酸残基。

J Pharmacol Exp Ther. 2010 Jan;332(1):66-75. doi: 10.1124/jpet.109.160465. Epub 2009 Oct 6.

Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis.Nrf2/Keap1 轴介导的氧化应激防护在原发性胆汁性胆管炎中受损。

Sci Rep. 2017 Mar 23;7:44769. doi: 10.1038/srep44769.

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Therapeutic potential of mesenchymal stem cell-derived extracellular vesicle in nonalcoholic fatty liver disease: a systematic review and meta-analysis of preclinical evidence.间充质干细胞衍生的细胞外囊泡在非酒精性脂肪性肝病中的治疗潜力：一项对临床前证据的系统评价和荟萃分析

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Regio- and Stereoselective Synthesis of Nitro-fatty Acids as NRF2 Pathway Activators Working under Ambient or Hypoxic Conditions.作为在常氧或低氧条件下起作用的NRF2途径激活剂的硝基脂肪酸的区域和立体选择性合成。

J Med Chem. 2025 Jun 12;68(11):12172-12184. doi: 10.1021/acs.jmedchem.5c00982. Epub 2025 May 26.

Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment.靶向NRF2的表观遗传和翻译后修饰：疾病治疗中的关键调控因子

Cell Death Discov. 2025 Apr 21;11(1):189. doi: 10.1038/s41420-025-02491-z.

Sphaeropsidin A covalently binds to Cys 151 of Keap1 to attenuate LPS-induced acute pneumonia in mice.球孢菌素A与Keap1的半胱氨酸151共价结合，以减轻脂多糖诱导的小鼠急性肺炎。

Redox Biol. 2025 May;82:103621. doi: 10.1016/j.redox.2025.103621. Epub 2025 Mar 27.

Identification and inhibition of PIN1-NRF2 protein-protein interactions through computational and biophysical approaches.通过计算和生物物理方法鉴定和抑制PIN1-NRF2蛋白-蛋白相互作用。

Sci Rep. 2025 Mar 14;15(1):8907. doi: 10.1038/s41598-025-89342-0.

Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases.健康立场文件与氧化还原观点——非传染性疾病中NRF2药理调节从 bench 到床边的转化

Redox Biol. 2025 Apr;81:103569. doi: 10.1016/j.redox.2025.103569. Epub 2025 Mar 3.

Considerations for antibody-based detection of NRF2 in human cells.基于抗体检测人细胞中NRF2的注意事项。

Redox Biol. 2025 Apr;81:103549. doi: 10.1016/j.redox.2025.103549. Epub 2025 Feb 12.

The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting.癌症中中性粒细胞的异质性及其对治疗靶点的意义。

Nat Immunol. 2025 Jan;26(1):17-28. doi: 10.1038/s41590-024-02029-y. Epub 2025 Jan 2.

Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases.用于研究NRF2在非传染性疾病中功能作用的模式生物。

Redox Biol. 2025 Feb;79:103464. doi: 10.1016/j.redox.2024.103464. Epub 2024 Dec 16.

Potential of NRF2 Inhibitors-Retinoic Acid, K67, and ML-385-In Overcoming Doxorubicin Resistance in Promyelocytic Leukemia Cells.NRF2 抑制剂-维甲酸、K67 和 ML-385 克服早幼粒细胞白血病细胞多柔比星耐药的潜力。

Int J Mol Sci. 2024 Sep 24;25(19):10257. doi: 10.3390/ijms251910257.

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Overlooked and valuable facts to know in the NRF2/KEAP1 field.

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