Department of Medical Oncology, Hospital Universitario La Paz, Madrid, Spain.
Department of Medical Oncology, Consorci Hospital General Universitari de Valencia, Valencia, Spain.
BMJ Support Palliat Care. 2024 Jan 8;13(e3):e847-e850. doi: 10.1136/spcare-2022-003882.
Intolerance of uncertainty (IU) has been linked to greater psychological distress, whereas hope appears to act as a protective factor against in patients with cancer. The aim of this study is to analyse the modifying effect of uncertainty in the presence of anxiety and depression in patients with advanced lung cancer.
Multicentre, prospective, observational, cross-sectional study of 145 individuals with advanced lung cancer. Participants completed the following questionnaires: IU Scale, Hert Hope Index, Brief Symptom Inventory.
Among patients with advanced lung cancer, anxiety and depression were prevalent, 30% and 35%, respectively. Uncertainty and hope with respect to their illness negatively affected their psychological distress. Hope and uncertainty accounted for 22% of the variance in anxiety and 34% of depressive symptoms. The hypothesised modifying effects (uncertainty×hope) was not supported in the depressive and anxious symptom models.
Our findings indicate that hope and uncertainty are important considerations in understanding mental health in people diagnosed with advanced lung cancer. Identifying patients who lack the resources needed to manage uncertainty and hope in relation to their disease could inform psychosocial intervention provision to improve quality of life.
不确定性容忍度（IU）与更大的心理困扰有关，而希望似乎是癌症患者的保护因素。本研究旨在分析焦虑和抑郁存在时不确定性对晚期肺癌患者的调节作用。
对 145 名晚期肺癌患者进行了多中心、前瞻性、观察性、横断面研究。参与者完成了以下问卷：不确定性量表、赫特希望指数、简明症状量表。
在晚期肺癌患者中，焦虑和抑郁的患病率分别为 30%和 35%。对疾病的不确定性和希望会对他们的心理困扰产生负面影响。希望和不确定性分别解释了焦虑症状的 22%和抑郁症状的 34%的方差。假设的调节效应（不确定性×希望）在抑郁和焦虑症状模型中没有得到支持。
我们的研究结果表明，希望和不确定性是理解确诊为晚期肺癌患者心理健康的重要因素。确定那些在疾病管理方面缺乏必要资源的患者，可以为改善生活质量提供心理社会干预措施。
