Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare, Moscow, Russian Federation.
City Clinical Cancer Hospital, Moscow, Russian Federation.
Drug Metab Pers Ther. 2021 Nov 30;37(3):223-228. doi: 10.1515/dmpt-2021-0162. eCollection 2022 Sep 1.
This review aimed to summarize the pharmacogenetic studies of the most commonly used drugs in the chemotherapy of gastrointestinal (GI) tumors: oxaliplatin, irinotecan, and fluoropyrimidines. So far, it has not been possible to develop an effective genotype-based approach for oxaliplatin. More and more evidence is emerging in favor of the fact that the choice of a dose of fluorouracil based on pharmacogenetic testing according to , can be not only effective but also cost-effective. Additional, well-planned trials of the genotype-based approach to irinotecan therapy are predicted to reduce adverse drug events in people with the genotypes and improve treatment efficacy in the rest of the patients, which might be cost-effective.
本综述旨在总结胃肠道（GI）肿瘤化疗中最常用药物的药物遗传学研究：奥沙利铂、伊立替康和氟嘧啶。到目前为止，还不可能针对奥沙利铂开发出一种有效的基于基因型的方法。越来越多的证据表明，根据 ，根据药物遗传学检测选择氟尿嘧啶剂量不仅有效而且具有成本效益。此外，预计针对伊立替康治疗的基于 基因型方法的进一步精心设计的试验将减少具有 基因型的患者的药物不良反应，并提高其余患者的治疗效果，这可能具有成本效益。
