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Combination of ezetimibe and moderate-intensity statin for patients with atherosclerotic cardiovascular disease: a paradigm shift in lipid management landscape.

作者信息

Pedicino Daniela, Volpe Massimo

机构信息

Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli 8, Rome 00168, Italy.

Cardiology Department, Sapienza University of Rome, Sant'Andrea Hospital, Via di Grottarossa 1035-1039, Rome 00189, Italy.

出版信息

Eur Heart J. 2022 Nov 1;43(41):4227-4228. doi: 10.1093/eurheartj/ehac502.

DOI:10.1093/eurheartj/ehac502
PMID:36101476
Abstract
摘要

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The absolute cardiovascular benefits of PCSK9 inhibitors and ezetimibe added to maximally tolerated statin therapy depend on individual baseline cardiovascular risk.在最大耐受剂量他汀类药物治疗基础上加用前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂和依折麦布的绝对心血管获益取决于个体基线心血管风险。
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IMPROVE-IT clinical implications. Should the "high-intensity cholesterol-lowering therapy" strategy replace the "high-intensity statin therapy"?IMPROVE-IT的临床意义。“高强度降低胆固醇治疗”策略是否应取代“高强度他汀类药物治疗”?
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A Bayesian network meta-analysis of PCSK9 inhibitors, statins and ezetimibe with or without statins for cardiovascular outcomes.基于贝叶斯网络的 PCSK9 抑制剂、他汀类药物和依折麦布联合或不联合他汀类药物用于心血管结局的荟萃分析。
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