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松鼠猴(松鼠猴属)实验性生殖器毛滴虫病

Experimental genital trichomoniasis in the squirrel monkey (Saimiri sciureus).

作者信息

Gardner W A, Culberson D E, Scimeca J M, Brady A G, Pindak F F, Abee C R

出版信息

Genitourin Med. 1987 Jun;63(3):188-91. doi: 10.1136/sti.63.3.188.

DOI:10.1136/sti.63.3.188
PMID:3610164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1194055/
Abstract

The squirrel monkey (Saimiri sciureus) has been proposed as a model for urogenital trichomoniasis in man, but has not been accepted as such because of the purported presence of naturally occurring vaginal trichomonads in this animal. The study published here shows that these are easily eradicated organisms of intestinal origin, which eliminates the potential confusion created by them. In addition, our experiments have shown that the hormonal status of primates seems to be a determinant in successfully establishing experimental trichomoniasis. This experimental infection recapitulates the clinical observations sufficiently to warrant the use of this model for studies of vaginal trichomoniasis.

摘要

松鼠猴(Saimiri sciureus)已被提议作为人类泌尿生殖系统滴虫病的模型,但由于据称该动物体内存在自然发生的阴道毛滴虫,它尚未被认可为这样的模型。此处发表的研究表明,这些是易于根除的肠道源性生物体,消除了它们造成的潜在混淆。此外,我们的实验表明,灵长类动物的激素状态似乎是成功建立实验性滴虫病的一个决定因素。这种实验性感染充分重现了临床观察结果,足以证明使用该模型研究阴道滴虫病是合理的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd2/1194055/ecc06adc2cd6/genitmed00063-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd2/1194055/ecc06adc2cd6/genitmed00063-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd2/1194055/ecc06adc2cd6/genitmed00063-0044-a.jpg

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Experimental genital trichomoniasis in the squirrel monkey (Saimiri sciureus).松鼠猴(松鼠猴属)实验性生殖器毛滴虫病
Genitourin Med. 1987 Jun;63(3):188-91. doi: 10.1136/sti.63.3.188.
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Front Immunol. 2017 Dec 14;8:1814. doi: 10.3389/fimmu.2017.01814. eCollection 2017.
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Clinical and microbiological aspects of Trichomonas vaginalis.阴道毛滴虫的临床和微生物学方面
Clin Microbiol Rev. 1998 Apr;11(2):300-17. doi: 10.1128/CMR.11.2.300.
3
Mouse intravaginal infection with Trichomonas vaginalis and role of Lactobacillus acidophilus in sustaining infection.小鼠阴道内感染阴道毛滴虫及嗜酸乳杆菌在维持感染中的作用。

本文引用的文献

1
Comparative pathogenicity of Trichomonas vaginalis and Trichomonas gallinae to mice. II. Histopathology of subcutaneous lesions.阴道毛滴虫和鸡毛滴虫对小鼠的致病性比较。II. 皮下病变的组织病理学
J Parasitol. 1962 Dec;48:898-918.
2
The establishment of various trichomonads of animals and man in axenic cultures.动物和人类各种毛滴虫在无菌培养中的建立。
J Parasitol. 1957 Aug;43(4):488-90.
3
Detection of endometrial carcinoma and hyperplasia in asymptomatic women.无症状女性子宫内膜癌和增生的检测。
Infect Immun. 1992 Jun;60(6):2375-9. doi: 10.1128/iai.60.6.2375-2379.1992.
Obstet Gynecol. 1984 Jul;64(1):1-11.
4
Infection of female squirrel monkeys (Saimiri sciureus) with trichomonas vaginalis as a model of trichomoniasis in women.将雌性松鼠猴(松鼠猴属)感染阴道毛滴虫作为女性滴虫病的模型。
Br J Vener Dis. 1983 Aug;59(4):249-54. doi: 10.1136/sti.59.4.249.
5
Immunoperoxidase staining of trichomonas vaginalis in cytologic material.
Acta Cytol. 1980 Sep-Oct;24(5):448-51.
6
Indigenous intravaginal pentatrichmonads vitiate the usefulness of squirrel monkeys (Saimiri sciureus) as models for trichomoniasis in men.本地阴道毛滴虫破坏了松鼠猴(松鼠猴属)作为男性滴虫病模型的效用。
Genitourin Med. 1985 Jun;61(3):212. doi: 10.1136/sti.61.3.212.
7
Tritrichomonas mobilensis n. sp. (Zoomastigophorea: Trichomonadida) from the Bolivian squirrel monkey Saimiri boliviensis boliviensis.来自玻利维亚松鼠猴(Saimiri boliviensis boliviensis)的活动三毛滴虫新种(动鞭纲:毛滴虫目)
J Protozool. 1986 May;33(2):301-4. doi: 10.1111/j.1550-7408.1986.tb05611.x.
8
Trichomonas vaginalis in the prostate gland.前列腺中的阴道毛滴虫。
Arch Pathol Lab Med. 1986 May;110(5):430-2.
9
Electron microscopy of Trichomonas vaginalis Donné: interaction with vaginal epithelium in human trichomoniasis.阴道毛滴虫(唐内氏)的电子显微镜检查:人类滴虫病中与阴道上皮的相互作用
Acta Pathol Microbiol Scand B. 1975 Aug;83(4):305-20. doi: 10.1111/j.1699-0463.1975.tb00107.x.